A systematic literature review of psychotherapeutic treatment of prolonged symptoms after mild traumatic brain injury

Bergersen, Kjersti; Halvorsen, Joar Øveraas; Tryti, Einar Aagaard; Taylor, Solveig Isabel; Olsen, Alexander

doi:10.1080/02699052.2016.1255779

Cited by 42 publications

(28 citation statements)

References 46 publications

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“…Common cognitive symptoms include problems with attention and memory, slow processing speed, difficulty multitasking, increased distractibility, losing one’s train of thought, and feeling foggy. Affective symptoms often reported by patients with mTBI include increased irritability, emotional lability, anxiety, and depression [ 17 , 18 ]. Fatigue is a frequent complaint after mTBI.…”

Section: Mild Traumatic Brain Injury Symptomsmentioning

confidence: 99%

Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology

Prince¹,

2017

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Awareness of mild traumatic brain injury (mTBI) and persisting post-concussive syndrome (PCS) has increased substantially in the past few decades, with a corresponding increase in research on diagnosis, management, and treatment of patients with mTBI. The purpose of this article is to provide a narrative review of the current literature on behavioral assessment and management of patients presenting with mTBI/PCS, and to detail the potential role of neuropsychologists and rehabilitation psychologists in interdisciplinary care for this population during the acute, subacute, and chronic phases of recovery.

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Section: Mild Traumatic Brain Injury Symptomsmentioning

confidence: 99%

Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology

Prince¹,

2017

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“…These effects are observed in absence of a diagnosable injury, and personnel remain fit for duty. Symptom reporting among operators with repetitive blast exposures are characterized, in part, by headaches, dizziness, taking longer to think, and tinnitus ( 11 – 13 ). Detection, prevention, or mitigation of these subconcussive, subacute, and chronic outcomes may be met by assessment of OP-mediated health effects that are measured acutely.…”

Section: Introductionmentioning

confidence: 99%

Overpressure Exposure From .50-Caliber Rifle Training Is Associated With Increased Amyloid Beta Peptides in Serum

et al. 2020

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Background: Overpressure (OP) is an increase in air pressure above normal atmospheric levels. Military personnel are repeatedly exposed to low levels of OP caused by various weapon systems. Repeated OP may increase risk of neurological disease or psychological disorder diagnoses. A means to detect early phase effects that may be relevant to brain trauma remain elusive. Therefore, development of quantitative and objective OP-mediated effects during acute timeframes would vastly augment point-of-care or field-based decisions. This pilot study evaluated the amplitude of traumatic brain injury (TBI)-associated biomarkers in serum as a consequence of repeated OP exposure from .50-caliber rifle use over training multiple days. Objective: To determine the acute temporal profile of TBI-associated serum biomarkers and their relationship with neurocognitive decrements or self-reported symptoms among participants exposed to low-level, repeated OP from weapons used in a training environment. Methods: Study participants were enrolled in .50-caliber sniper rifle training and exposed to mild OP (peak pressure 3.8-4.5 psi, impulse 19.27-42.22 psi-ms per day) for three consecutive days (D1-D3). Defense automated neurobehavioral assessment (DANA) neurocognitive testing, symptom reporting, and blood collection were conducted 2-3 h before (pre-) and again 0.45-3 h after (post-) OP exposure. The TBI-associated serum biomarkers, glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilament light (Nf-L), tau, and amyloid beta peptides (Aβ-40 and Aβ-42) were measured using digital ELISAs. Results: Serum GFAP decreased on D1 and D3 but not D2 after OP exposure. Nf-L was suppressed on D3 alone. Aβ-40 was elevated on D2 alone while Aβ-42 was elevated each day after OP exposure. Suppression of GFAP and elevation of Aβ-42 correlated to OP-mediated impulse levels measured on D3. Thangavelu et al. Amyloid Beta Peptides After Overpressure Conclusions: Acute measurement of Aβ-peptides may have utility as biomarkers of subconcussive OP caused by rifle fire. Fluctuation of GFAP, Nf-L, and particularly Aβ peptide levels may have utility as acute, systemic responders of subconcussive OP exposure caused by rifle fire even in the absence of extreme operational deficits or clinically defined concussion.

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“…Mild TBI (mTBI), the most common form of TBI in high-impact sports,6 can lead to a wide array of cognitive, emotional, and somatic symptoms 7. The most frequently reported symptoms include fatigue, headaches, memory impairment, concentration deficits, and sleep-related problems 6.…”

Section: Introductionmentioning

confidence: 99%

“…The most frequently reported symptoms include fatigue, headaches, memory impairment, concentration deficits, and sleep-related problems 6. The majority of patients achieve complete resolution of symptoms quickly after a mTBI, but 10–20% may develop persisting symptoms 7. In fact, neuropsychological testing revealed persistent cognitive impairments in boxers following mTBI extending beyond the subjectively symptomatic period 6…”

Section: Introductionmentioning

confidence: 99%

<p>Impact of traumatic brain injury on sleep: an overview</p>

Aoun¹,

Rawal²,

Attarian³

et al. 2019

NSS

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Traumatic brain injury (TBI) is a global health problem that affects millions of civilians, athletes, and military personnel yearly. Sleeping disorders are one of the underrecognized sequalae even though they affect 46% of individuals with TBI. After a mild TBI, 29% of patients have insomnia, 25% have sleep apnea, 28% have hypersomnia, and 4% have narcolepsy. The type of sleep disturbance may also vary according to the number of TBIs sustained. Diffuse axonal injury within the sleep regulation system, disruption of hormones involved in sleep, and insults to the hypothalamus, brain stem, and reticular activating system are some of the proposed theories for the pathophysiology of sleep disorders after TBI. Genetic and anatomical factors also come to play in the development and severity of these sleeping disorders. Untreated sleep disturbances following TBI can lead to serious consequences with respect to an individual’s cognitive functioning. Initial management focuses on conservative measures with progression to more aggressive options if necessary. Future research should attempt to establish the effectiveness of the treatments currently used, as well as identify manageable co-existing factors that could be exacerbating sleep disorders.

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A systematic literature review of psychotherapeutic treatment of prolonged symptoms after mild traumatic brain injury

Cited by 42 publications

References 46 publications

Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology

Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology

Overpressure Exposure From .50-Caliber Rifle Training Is Associated With Increased Amyloid Beta Peptides in Serum

<p>Impact of traumatic brain injury on sleep: an overview</p>

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