Employing the activation technique in combination with radiochemical separations and high-resolution γ -ray spectroscopy fission neutron spectrum averaged cross sections were measured for several (n, 2n), (n, p) and (n, α) reactions on isotopes of dysprosium; our measurements constitute the first systematic studies. Of special interest was the investigation of the 156 Dy(n, α) 153 Gd reaction for the production of no-carrier-added 153 Gd in a nuclear reactor. Using 100% enriched 156 Dy target, 8633 KBq of 153 Gd per batch can be produced which is, however, not sufficient for medical application.