A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

Zhang, Luoping; Louie, Allen; Rigutto, Gabrielle; Guo, Helen; Zhao, Yun; Ahn, Stacy; Dahlberg, Sarah; Sholinbeck, Michael; Smith, Martyn T.

doi:10.1016/j.envres.2022.115188

Cited by 24 publications

(9 citation statements)

References 114 publications

(146 reference statements)

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“…Upregulation of inflammatory responses due to PFOS exposure is also supported by studies reporting inflammasome activation and subsequent cytokine release by pyroptotic cells ( Zhang et al, 2023 ). For instance, the mechanism associated with PFOS-induced lung inflammation in offspring rats was upregulation of inflammasome-associated proteins, such as NLRP3, ASC, Caspase-1, and GSDMD, and an increase in inflammatory cytokines IL-18 and IL-1β ( Zhang et al, 2021 ).…”

Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 75%

“…Evidence in the literature suggests that PFOS can promote chronic inflammation by inducing an increase in pro-inflammatory cytokine production. Although some data are still controversial, the most well-represented cytokines are TNF-α, IL-6, and IL-1β ( Temkin et al, 2020 ; Elmore et al, 2021 ; Zhang et al, 2023 ). A study by Diaz et al determined that PFOS enhanced pro-inflammatory cytokine expression in zebrafish and mice.…”

Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 99%

“…Another mechanism by which PFOS exposure may be related to tumorigenesis is through its ability to decrease immune system function, leading to immunosuppression. Some studies have reported a reduction in circulating immunoglobulins, such as IgM and IgG, as well as a decrease in the activity or proliferation of natural killer (NK) cells, B cells, and CD4 + CD8 + T-cell subtypes ( Temkin et al, 2020 ; Elmore et al, 2021 ; Zhang et al, 2023 ). The immune system plays a crucial role in preventing tumor development.…”

Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 99%

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The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis

Durham,

Tessmann,

Deng

et al. 2023

Front. Toxicol.

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PFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine atoms. PFAS substances that have longer carbon chains, such as PFOS (perfluorooctane sulfonic acid), can potentially pose a significant public health risk due to their ability to bioaccumulate and persist for long periods of time in the body and the environment. The National Academies Report suggests there is some evidence of PFOS exposure and gastrointestinal (GI) inflammation contributing to ulcerative colitis. Inflammatory bowel diseases such as ulcerative colitis are precursors to colorectal cancer. However, evidence about the association between PFOS and colorectal cancer is limited and has shown contradictory findings. This review provides an overview of population and preclinical studies on PFOS exposure and GI inflammation, metabolism, immune responses, and carcinogenesis. It also highlights some mitigation approaches to reduce the harmful effects of PFOS on GI tract and discusses the dietary strategies, such as an increase in soluble fiber intake, to reduce PFOS-induced alterations in cellular lipid metabolism. More importantly, this review demonstrates the urgent need to better understand the relationship between PFOS and GI pathology and carcinogenesis, which will enable development of better approaches for interventions in populations exposed to high levels of PFAS, and in particular to PFOS.

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Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 75%

Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 99%

Section: Pfos Exposure and Gi Carcinogenesis In Animal Studiesmentioning

confidence: 99%

See 1 more Smart Citation

The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis

Durham,

Tessmann,

Deng

et al. 2023

Front. Toxicol.

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“…Moreover, recent evidence from mapping analyses shows that PFAS exposure is associated with chronic systemic inflammation across multiple models that may also perturb vascular homeostasis. 142 More research is needed to define the relationship of PFAS with inflammatory activation (eg, measures of C-reactive protein and IL-1β) in humans. Moreover, a notable limitation of the existing literature is the observational nature of the studies that are subject to confounding.…”

Section: Gaps In Researchmentioning

confidence: 99%

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Schlezinger,

Gokce

2024

Circulation Research

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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“…(11) To date, there are a limited number of studies that have investigated the association between PFAS and cytokine levels circulating in human serum, the latter serving as a surrogate measure for immune function. (12) Two cross-sectional studies conducted in the United States reported elevated inverse associations of PFOS and per uorononanoic acid (PFNA) exposure and IL-8 levels (13) as well as increased PFAS exposure inversely associated with TNF-α (14). Another cross-sectional study among children in Taiwan reported an increase in PFAS exposure linked to asthma severity, increased IgE levels, increased absolute eosinophil counts, and increased eosinophilic cationic protein.…”

Section: Introductionmentioning

confidence: 99%

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

Cauble,

Reynolds,

Epeldegui

et al. 2024

Preprint

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Background Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that have been shown to cause or are related to various health outcomes and diseases.Methods In this cross-sectional study nested in the California Teachers Study cohort, we measured PFAS exposure (9 analytes) in serum, and further evaluated the 4 PFAS analytes (PFHxS, PFNA, PFOA, PFOS) with detection levels of > 80%, in relation to 16 systemic inflammatory/immune markers in two multiplex serum-based assays from blood collected at one point in time. Study participants (n = 722) were female, completed a questionnaire regarding various health measures and behaviors, and donated a blood sample between 2013–2016. The association between PFAS analytes and immune markers (dichotomized by median) were evaluated by calculating odds ratios (OR) and 95% confidence intervals (CI), in both linear and logistic regression models, adjusted for age.Results The median age of our study population was 61 years (range = 40–95 years), of whom 99.7% had detectable levels of at least one PFAS analyte. The prevalence of PFAS analytes was strongly correlated with age, with those aged 40–49 years (youngest group) having the lowest PFAS burden and those aged 75 + years (oldest group) with the highest detectable levels. Statistically significant positive associations were observed between each ng/mL increase in PFHxS (OR = 1.34), PFOA (OR = 1.15), and PFOS (OR = 1.53) levels with BAFF levels above the median (compared to below the median). There was a 1.47-fold increase of elevated PFHxS with TNF-RII (above median) and a 1.38-fold increase with IL2Rα. We observed statistically significant inverse associations between PFOA and IL6 (OR = 0.79), and between PFNA with sCD14 (OR = 0.86) and CD27 (OR = 0.80). Risk estimates for logistic regression models were consistent. No significant positive associations were observed between PFNA exposure and any immune marker.Conclusions PFAS exposure was associated with altered levels of circulating inflammatory/immune markers. If validated, our results may suggest potential immune mechanisms underlying associations between the different PFAS analytes and adverse health outcomes.

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A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

Cited by 24 publications

References 114 publications

The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis

The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

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