A Systematic Evaluation of Factors Associated With Nocturia—The Population-based FINNO Study

Tikkinen, Kari A.O.; Auvinen, Anssi; Johnson, Theodore M.; Weiss, Jeffrey P.; Keränen, Tapani; Tiitinen, Aila; Polo, Olli; Partinen, Markku; Tammela, Teuvo L.J.

doi:10.1093/aje/kwp133

Cited by 156 publications

(188 citation statements)

References 59 publications

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“…In addition, the lack of arginine vasopressin (AVP) secretion and renal AVP resistance induced by diabetes may play a crucial role (20,21). People with obesity (BMI of > 27 kg/m 2 ) had higher odds for suffering from nocturia, as compared to those without obesity, which was consistent with numerous epidemiological studies (5,7,8,15,17). The exact mechanism by which obesity causes nocturia is not known.…”

Section: Discussionsupporting

confidence: 63%

“…Clinical observations have indicated that some chronic illnesses are associated with nocturia. The Tikkinen et al study reported that being overweight or obese, having coronary artery disease or diabetes in women and obesity in men, were signifi cantly associated with nocturia in Finland (8). The Gourova et al study revealed that cardiovascular disease, hypertension, diabetes mellitus/insipidus, and cerebrovascular disease were independent risk factors for nocturia in men aged 55-75 years in the Netherlands (9).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, to our knowledge, most published literatures were conducted in the western world (7)(8)(9)(10)(11). The data from Asia are relatively limited.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for nocturia in middle-aged and elderly people from public health centers in Taiwan

et al. 2012

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Purpose: To assess the occurrence and the associated risk factors for nocturia among middle-aged and elderly people from public health centers in southern Taiwan. Materials and Methods: Data were part of our previous cross-sectional study which used a self-administered questionnaire for the assessment of lower urinary tract symptoms. A total of 1011 responders who were at least 40 years of age were enrolled from any of four local public health centers for any reason in Pingtung County, Taiwan. Nocturia, as a dependent variable, was defi ned as two or more episodes per night. Covariables included age, gender, and chronic illnesses (obesity, hypertension, diabetes, cardiovascular disease, and stroke). Multivariate logistic regression was applied to determine the risk factors associated with nocturia. A p-value of less than 0.05 was considered statistically signifi cant. Results: About 38.1% (385/1011) of the participants reported having nocturia  2 episodes/night, and the occurrence of nocturia increased with advanced age. More than half (51.2%, 197/385) participants with nocturia perceived at least "a bit of a problem" on the sleep quality. The multivariate logistical regression showed that the independent risk factors for nocturia were age (OR:1.06, CI:1.05-1.08), hypertension (OR:1.58, CI:1.16-2.16) and diabetes (OR:1.59, CI:1.03-2.45) and obesity (OR:1.47, CI:1.02-2.10), while a borderline effect on nocturia was produced by cardiovascular disease (OR:1.66, CI: 0.98-2.79) and stroke (OR:2.75, CI:0.88-8.64). Conclusions: Several chronic illnesses coexisted with nocturia. Health care providers need to be aware of an increased risk of nocturia among people with certain chronic illnesses, and provide appropriate health care.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for nocturia in middle-aged and elderly people from public health centers in Taiwan

et al. 2012

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“…Therefore, it is conceivable that going to the toilet because of the inability to sleep may lead to nocturia. It has been reported that nocturia and lower urinary tract symptoms are related in men and women [16]. The results of the present study indicated the same influence of lower urinary tract symptoms on nocturia.…”

Section: Discussionsupporting

confidence: 81%

Factors Related to Nocturia in Elderly People Living in Local Remote Area in Japan

Takeda¹,

Ono²,

Kanda³

et al. 2017

Health

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The elderly people are prone to be affected by quality of life (QOL) by nocturia becoming the multiple times. A purpose of this study was to determine it about a factor associated with the night urination. This survey was conducted in 2015 as a cross-sectional study. Anonymous, self-administered questionnaires were used to prevent individuals from being identified. The analysis subjects were 699 elderly people with the nocturia which belonged to club of the aged 65 years or older. Those with nocturia were placed in the Nocturia-1 group if they reported experiencing nocturia once per night or in the Nocturia-≥ 2 group if they reported experiencing nocturia two or more times per night. We analyzed the relationships between the characteristics, lower urinary tract symptoms, and opportunities to go outdoors in the Nocturia-1 and Nocturia-≥ 2 groups based on sex using the x 2 test. In addition, to investigate the factors that influence the change from nocturia once per night to two or more times per night, we performed logistic regression analysis using the x 2 test on the characteristics and lower urinary tract symptoms that showed significant differences separately for men and women. Among the men, factors with a significant positive relationship were age, diabetes mellitus, lower back pain, daytime frequency, and urinary urgency. Among the women, factors with a significant positive relationship were age, requiring support 1-requiring long-term care 2, urinary urgency, and feeling of incomplete emptying. It was suggested that the life of elderly people improved by nocturia not increasing.

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“…[14] However, as with Wuerstle, the analysis was unadjusted for the influence of comorbid risk factors.. Another study of nocturia conducted in Finland found antidepressants positively associated with nocturia (OR=3.16, 95% CI: 1.29-7.73) after multivariate adjustment, but only among men. [38] The subtypes of antidepressants studied were not defined. Finally, a recent longitudinal analysis found that men with depression at baseline were more likely to develop moderate to severe nocturia five years later, with an effect apparent only in those whose depression was not drug-treated; antipsychotics were also not associated with incident nocturia.…”

Section: Discussionmentioning

confidence: 99%

1726 Are Commonly-Used Psychoactive Medications Associated With Lower Urinary Tract Symptoms?

et al. 2012

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Purpose-Lower urinary tract symptoms (LUTS) such as urinary frequency and urgency are bothersome and associated with reduced quality-of-life. Atypical antipsychotics (AAPs) have been implicated in increasing the risk of urinary incontinence. In a large community-based sample of men and women, we examined the associations of AAP use and selective serotonin reuptake inhibitor (SSRIs) use with LUTS.Methods-Data were collected (2002)(2003)(2004)(2005)) from a generalizable sample of Boston, MA, USA residents aged 30-79 (N=5503). LUTS were assessed using the American Urologic Association Symptom Index (AUA-SI). The prevalence of clinically-significant LUTS was estimated using a cutoff AUA-SI score of 8+ to indicate moderate-to-severe symptoms. Confounder-adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated from multivariate logistic regression to estimate the associations for psychoactive drugs used in the previous month (SSRIs, AAPs, both) and LUTS.Results-Among women, AAP users had a higher prevalence of LUTS (46.2%) compared to SSRI users (23.5%) and those with depressive symptoms not using SSRIs or AAPs (26.3%). Corresponding prevalence estimates among men were 32.7%, 29.8%, and 33.3%. In multivariate models, AAP use was significantly associated with LUTS among women when used either with SSRIs (OR=2.72, or without SSRIs (OR=3.05,) but SSRI use without AAP use was not associated with LUTS, compared to non-users without depressive symptoms. No associations were observed among men.Conclusions-In our study, AAPs but not SSRIs were associated with increased prevalence of LUTS among women only. Further prospective research is needed to determine time sequence and cause-and-effect.

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A Systematic Evaluation of Factors Associated With Nocturia—The Population-based FINNO Study

Cited by 156 publications

References 59 publications

Prevalence and risk factors for nocturia in middle-aged and elderly people from public health centers in Taiwan

Prevalence and risk factors for nocturia in middle-aged and elderly people from public health centers in Taiwan

Factors Related to Nocturia in Elderly People Living in Local Remote Area in Japan

1726 Are Commonly-Used Psychoactive Medications Associated With Lower Urinary Tract Symptoms?

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