A System of Staging Musculoskeletal Neoplasms

Enneking, William F.

doi:10.1097/00003086-198603000-00003

Cited by 879 publications

(582 citation statements)

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“…The average age at the time of surgery was 37 years (range 10-78 years). With regard to staging, one sarcoma was staged as IA (1.9%), four as stage IB (7.8%), three as stage IIA (5.9%), 32 as stage IIB (62.7%), and nine as stage III (17.6%) in the Enneking classification [12]. The mean follow-up period was 19 months (median, 16 months; range, 3-63 months).…”

Section: Methodsmentioning

confidence: 99%

Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Hardes

Eiff

Streitbuerger

et al. 2010

Journal of Surgical Oncology

301

225

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Background and Objectives: The placement of megaprostheses in patients with bone sarcoma is associated with high rates of infection, despite prophylactic antibiotic administration. In individual cases, secondary amputation is unavoidable in the effort to cure infection. Methods: The infection rate in 51 patients with sarcoma (proximal femur, n ¼ 22; proximal tibia, n ¼ 29) who underwent placement of a silver-coated megaprosthesis was assessed prospectively over a 5-year period, along with the treatment administered for infection. The infection rate was compared with the data for 74 patients in whom an uncoated titanium megaprosthesis (proximal femur, n ¼ 33; proximal tibia, n ¼ 41) was implanted. Results: The infection rate was substantially reduced from 17.6% in the titanium to 5.9% in the silver group. Whereas 38.5% of patients in the titanium group ultimately had to undergo amputation when periprosthetic infection developed, these mutilating surgical procedures were not necessary in the study group. Conclusions: The use of silver-coated prostheses reduced the infection rate in the medium term. In addition, less aggressive treatment of infection was possible in the group with silver-coated prostheses. Further studies with longer term follow-up periods and larger numbers of patients are warranted in order to confirm these encouraging results.

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Section: Methodsmentioning

confidence: 99%

Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Hardes

Eiff

Streitbuerger

et al. 2010

Journal of Surgical Oncology

301

225

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show abstract

“…Starting at the year of 2000, MRI was also performed. The cases were staged according to the Enneking system: st.2 for active lesions and st.3 for benign aggressive lesions [12]. This staging system has recently been submitted to a intra and interobserver reliability study which confirmed its validity [13].…”

Section: Methodsmentioning

confidence: 99%

“…At the beginning of the activity of the senior surgeon (SB), a review of 30 cases of surgically treated OBL of the mobile spine was performed [11] where, the Enneking staging system [12] was retrospectively applied. Local recurrence occurred in 4 out of 30 patients (13.3 %), seven percent rate of local recurrence was found in stage two (st.2) (1 patient out of 14) while for stage three(st.3), it was as high as 19 % (3 out of 16).…”

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confidence: 99%

Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases

et al. 2012

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“…Dedifferentiated chondrosarcoma is defined by the presence of a biphasic tumor composed of a conventional chondrosarcoma (usually Grade 1) and a high-grade, noncartilage-producing sarcoma [3]. Clinically these tumors can be divided into low grade (Grade 1) and high grade (Grade 2, Grade 3, and dedifferentiated) [9].…”

Section: Introductionmentioning

confidence: 99%

Is Needle Biopsy Clinically Useful in Preoperative Grading of Central Chondrosarcoma of the Pelvis and Long Bones?

Roitman

Farfalli

Ayerza

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Background Central chondrosarcoma of bone is graded on a scale of 1 to 3 according to histological criteria. Clinically, these tumors can be divided into low-grade (Grade 1) and high-grade (Grade 2, Grade 3, and dedifferentiated) chondrosarcomas. Although en bloc resection has been the most widely used treatment, it has become generally accepted that in selected patients with low-grade chondrosarcomas of long bones, curettage is safe and effective. This approach requires an accurate preoperative estimation of grade to avoid under-or overtreatment, but prior reports have indicated that both imaging and biopsy do not always give an accurate prediction of grade. Questions/purposes (1) What is the concordance of image-guided needle preoperative biopsy and postoperative grading in central (intramedullary) chondrosarcomas of long bones, and how does this compare with the concordance of image-guided needle preoperative biopsy and postoperative grading in central pelvic chondrosarcomas? (2) What is the concordance of preoperative image-guided needle biopsy and postoperative findings in differentiating low-grade from high-grade central chondrosarcomas of long bones, and how does this compare with the concordance in central pelvic chondrosarcomas? Methods Between 1997 and 2014, in our institution, we treated 126 patients for central chondrosarcomas located in long bones and the pelvis. Of these 126 cases, 41 were located in the pelvis and the remaining 85 cases were located in long bones. This study considers 39 (95%) and 40 (47%) of them, respectively. We included all cases in which histological information was complete regarding preoperative and postoperative tumor grading. We excluded all cases with incomplete data sets or nondiagnostic preoperative biopsies. To evaluate the needle biopsy accuracy, we compared the histological tumor grade, obtained from the preoperative biopsy, with the final histological grade obtained from the postoperative surgical specimen. The weighted and nonweighted kappa statistics were used to evaluate the agreement. Results Concordance between the preoperative biopsy and the final pathological analysis in terms of histological grade was much higher in long-bone chondrosarcoma than in pelvic chondrosarcoma (83% [33 of 40] versus 36% [14 of 39]; odds ratio, 8, 48). Likewise, the weighted kappa coefficients were higher in long-bone chondrosarcoma than One of the authors certifies that he (LAA-T) or a member of his immediate family, has or may receive payments or benefits, during the study period, an amount of USD 10,000 to USD 100,000 from Stryker Americas (Miramar, FL, USA). All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research 1 editors and board members are on file with the publication and can be viewed on request. Each author certifies that his institution has approved the reporting of this study and that all investigations were conducted in conformity with ethical principles of research. This work was performed at the Italian Hospital of Bue...

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A System of Staging Musculoskeletal Neoplasms

Cited by 879 publications

References 0 publications

Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Reduction of periprosthetic infection with silver‐coated megaprostheses in patients with bone sarcoma

Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases

Is Needle Biopsy Clinically Useful in Preoperative Grading of Central Chondrosarcoma of the Pelvis and Long Bones?

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