A System-based Approach for the Evaluation of Electromechanical Properties of Brain Tumors

Arjun, B S; Sitaramgupta, V S N V; Aswin, S; Rao, Shilpa; Pandya, Hardik J.

doi:10.1109/embc48229.2022.9871879

2022 44th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC) 2022

DOI: 10.1109/embc48229.2022.9871879

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A System-based Approach for the Evaluation of Electromechanical Properties of Brain Tumors

B S Arjun

V S N V Sitaramgupta

S Aswin

et al.

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2024

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Bilayer surrogate brain response under various blast loading conditions

Norris,

Arnold,

Wilkes

et al. 2024

Shock Waves

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Variations in the experimental constraints applied within blast simulations can result in dramatically different measured biomechanical responses. Ultimately, this limits the comparison of data between research groups and leads to further inquisitions about the “correct” biomechanics experienced in blast environments. A novel bilayer surrogate brain was exposed to blast waves generated from advanced blast simulators (ABSs) where detonation source, boundary conditions, and ABS geometry were varied. The surrogate was comprised of Sylgard 527 (1:1) as a gray matter simulant and Sylgard 527 (1:1.2) as a white matter simulant. The intracranial pressure response of this surrogate brain was measured in the frontal region under primary blast loading while suspended in a polyurethane spherical shell with 5 mm thickness and filled with water to represent the cerebrospinal fluid. Outcomes of this work discuss considerations for future experimental designs and aim to address sources of variability confounding interpretation of biomechanical responses.

show abstract

Bilayer surrogate brain response under various blast loading conditions

Norris,

Arnold,

Wilkes

et al. 2024

Shock Waves

View full text Add to dashboard Cite

show abstract

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A System-based Approach for the Evaluation of Electromechanical Properties of Brain Tumors

Cited by 1 publication

References 34 publications

Bilayer surrogate brain response under various blast loading conditions

Bilayer surrogate brain response under various blast loading conditions

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