A Synthetic Total Impulse Response Characterization Method for Correction of Hand-Held Optoacoustic Images

Chowdhury, Kaushik; Prakash, Jaya; Karlas, Angelos; Jüstel, Dominik; Ntziachristos, Vasilis

doi:10.1109/tmi.2020.2989236

Cited by 38 publications

(44 citation statements)

References 56 publications

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“…This compensation was achieved by experimentally measuring the spatial transfer function and applying it as a multiplicative weighting function in the frequency domain inversion scheme of the acquired RSOM data. Although incorporating the PSF has been shown to successfully improve the quality of reconstructed optoacoustic images 30,46,47 and detector sensitivity fields have been included in reconstruction algorithms to account for negatively focused ultrasound transducers 48,49 , these studies were performed in the time-domain and suffered from long processing times. Here we incorporate the PSF correction factor in the reconstruction problem in the Fourier domain to avoid sacrificing computational time.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Three-Dimensional Raster Scan Optoacoustic Mesoscopy Using Frequency Domain Inversion

Mustafa

Omar

Prade

et al. 2021

IEEE Trans. Med. Imaging

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Optoacoustic signals are typically reconstructed into images using inversion algorithms applied in the time-domain. However, time-domain reconstructions can be computationally intensive and therefore slow when large amounts of raw data are collected from an optoacoustic scan. Here we consider a fast weighted -(FWOK) algorithm operating in the frequency domain to accelerate the inversion in raster-scan optoacoustic mesoscopy (RSOM), while seamlessly incorporating impulse response correction with minimum computational burden. We investigate the FWOK performance with RSOM measurements from phantoms and mice in vivo and obtained 360-fold speed improvement over inversions based on the back-projection algorithm in the time-domain. This previously unexplored inversion of in vivo optoacoustic data with impulse response correction in frequency domain reconstructions points to a promising strategy of accelerating optoacoustic imaging computations, toward video-rate tomography.

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Section: Discussionmentioning

confidence: 99%

In Vivo Three-Dimensional Raster Scan Optoacoustic Mesoscopy Using Frequency Domain Inversion

Mustafa

Omar

Prade

et al. 2021

IEEE Trans. Med. Imaging

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“…TIR model in handheld optoacoustic tomography. For currently emerging limited view handheld transducers in clinical applications, the forward TIR model [4] incorporating transducer properties and refraction of acoustic waves at the interface between sample and coupling medium can be written as…”

Section: Thorough Experimental Characterization Of Such Systems Is Often Laborious and Impractical A Shortcoming Of The Existing Impulse mentioning

confidence: 99%

“…If the location of the pixels at r in the FOV is indexed by −6 dB bandwidth of 50% as characterized by the manufacturer in transmit/receive mode. Details of the imaging system can be found in [4]. For characterization of the handheld scanner, a two-axis translation stage was built using motorized linear translation stages from Thorlabs, USA.…”

Section: Correcting For Individual Transducer Responses We Demon-mentioning

confidence: 99%

Individual transducer impulse response characterization method to improve image quality of array-based handheld optoacoustic tomography

Chowdhury¹,

Bader²,

Dehner³

et al. 2020

Opt. Lett.

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The physical properties of each transducer element play a vital role in the quality of images generated in optoacoustic (photoacoustic) tomography using transducer arrays. Thorough experimental characterization of such systems is often laborious and impractical. A shortcoming of the existing impulse response correction methods, however, is the assumption that all transducers in the array are identical and therefore share one electrical impulse response (EIR). In practice, the EIRs of the transducer elements in the array vary, and the effect of this element-to-element variability on image quality has not been investigated so far, to the best of our knowledge. We hereby propose a robust EIR derivation for individual transducer elements in an array using sparse measurements of the total impulse response (TIR) and by solving the linear system for temporal convolution. Thereafter, we combine a simulated spatial impulse response with the derived individual EIRs to obtain a full characterization of the TIR, which we call individual synthetic TIR. Correcting for individual transducer responses, we demonstrate significant improvement in isotropic resolution, which further enhances the clinical potential of array-based handheld transducers.

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“…Modern MSOT is equipped with hand-held probes that consist of the illumination unit and the ultrasound detector and offer dual operation (MSOT/US) by also performing ultrasound imaging. In analogy to stand-alone ultrasonography, the handheld MSOT probe is placed on the skin and records high-resolution (≈ 200−300 μm) tomographic images at depths of ≈ 2−4 cm with a field of view of ≈ 4 cm [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis

et al. 2021

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Several imaging techniques aim at identifying features of carotid plaque instability but come with limitations, such as the use of contrast agents, long examination times and poor portability. Multispectral optoacoustic tomography (MSOT) employs light and sound to resolve lipid and hemoglobin content, both features associated with plaque instability, in a label-free, fast and highly portable way. Herein, 5 patients with carotid atherosclerosis, 5 healthy volunteers and 2 excised plaques, were scanned with handheld MSOT. Spectral unmixing allowed visualization of lipid and hemoglobin content within three ROIs: whole arterial cross-section, plaque and arterial lumen. Calculation of the fat-blood-ratio (FBR) value within the ROIs enabled the differentiation between patients and healthy volunteers (P = 0.001) and between plaque and lumen in patients (P = 0.04). Our results introduce MSOT as a tool for molecular imaging of human carotid atherosclerosis and open new possibilities for research and clinical assessment of carotid plaques.

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A Synthetic Total Impulse Response Characterization Method for Correction of Hand-Held Optoacoustic Images

Cited by 38 publications

References 56 publications

In Vivo Three-Dimensional Raster Scan Optoacoustic Mesoscopy Using Frequency Domain Inversion

In Vivo Three-Dimensional Raster Scan Optoacoustic Mesoscopy Using Frequency Domain Inversion

Individual transducer impulse response characterization method to improve image quality of array-based handheld optoacoustic tomography

Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis

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