2003
DOI: 10.1016/s1043-4666(03)00101-7
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A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

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Cited by 113 publications
(109 citation statements)
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“…[42][43][44][45] We show that intraperitoneal administration of these blocking peptides to mice exposed to PD fluid preserved the peritoneal morphology and function and decreased the accumulation of different subpopulations of "fibroblast-specific protein-1" (FSP-1) fibroblasts, especially of those co-expressing the mesothelial marker cytokeratin. These cells with intermediate phenotype (Cyto ϩ /FSP-1 ϩ ) displayed myofibroblastlike characteristics including fibrogenic capacity.…”
mentioning
confidence: 89%
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“…[42][43][44][45] We show that intraperitoneal administration of these blocking peptides to mice exposed to PD fluid preserved the peritoneal morphology and function and decreased the accumulation of different subpopulations of "fibroblast-specific protein-1" (FSP-1) fibroblasts, especially of those co-expressing the mesothelial marker cytokeratin. These cells with intermediate phenotype (Cyto ϩ /FSP-1 ϩ ) displayed myofibroblastlike characteristics including fibrogenic capacity.…”
mentioning
confidence: 89%
“…42 P144 is a synthetic 14-mer peptide designed from the TGF-␤1 type III receptor (TSLDASIIWAMMQN) that has been shown to bind TGF-␤1 and to inhibit its activity in vitro and in vivo. 43,44 As a control, Figure 7. TGF-␤1-blocking peptides reduce the number of fibroblasts derived from bone-marrow-recruited cells.…”
Section: Peptides and Adenoviral Vectorsmentioning
confidence: 99%
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“…To inhibit the activity of TGF-b and COX-2, these mice were treated for 15 days with TGF-b inhibitory peptide P144 [49], a control peptide, or indomethacin during the course of blood-stage infection. We found that both TGF-b and COX-2 activities appear to mediate the inhibition of CD8 + T cell responses in vivo, as inhibiting either of these activities restored the CD8 + T cell response (Fig.…”
Section: Pge 2 and Tgf-b Inhibit Cd8 + T Cell Responses Against The Lmentioning
confidence: 99%