A synthetic method to assay polycystin channel biophysics
Megan Larmore,
Orhi Esarte Palomero,
Neha P. Kamat
et al.
Abstract:Ion channels are biological transistors that control flux of ions across membranes to regulate electrical transmission and cell signaling. They are found in all eukaryotic cell membranes and their conductive states are frequently disrupted in human diseases. Organelle ion channels are among the most resistant to functional and pharmacological interrogation. Traditional channel protein reconstitution methods rely upon exogenous expression and/or purification from endogenous cellular sources which are frequently… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.