A Synthetic Hydrogel with Thermoreversible Gelation. I. Preparation and Rheological Properties

Combination Therapy of Surgical Tumor Resection with Implantation of a Hydrogel Containing Camptothecin-Loaded Poly(lactic-<i>co</i>-glycolic acid) Microspheres in a C6 Rat Glioma Model

“…The unique temperature kinetics of TGP have been previously reported. [10][11][12][13] At low temperatures (<32°C), amide groups are hydrated, which converts the polymer into the sol state. At high temperatures (around body temperature), the hydrogen bonds between the amide groups and water molecules dissociate and the polymer chains aggregate because of the hydrophobic interactions mediated by the isopropyl groups, causing the polymer to transition to the gel state.…”

“…9) Thermoreversible gelation polymer (TGP) hydrogel (Mebiol TM Gel) is a gel at body temperature and a sol at rozom temperature. [10][11][12][13] Therefore, when the formulation (drug/PLGA microspheres dispersed in TGP sol) is injected into the target site, TGP is thought to form a gel around the injection site, retain the drug/PLGA microspheres, and not diffuse across the entire brain tissue. PLGA is a biodegradable polymer that has been used as a base for the delivery of long-term sustained-release microspheres.…”

In vitro culture and characterization of enteric neural precursor cells from human gut biopsy specimens using polymer scaffold

“…Cell count of the pellet was obtained using the Trypan blue dye exclusion method and the cells were divided into two equal portions. The cells thus divided were seeded as two groups, Group I (Gr.I): in DMEM/F12 (Gibco BRL, Gaithersburg, MD, USA) medium supplemented with penicillin (100 U/mL), streptomycin (100 µg/mL), L-glutamine (2 mmol/L), and growth factors including basic fibroblast growth factor (bFGF) (20 ng/mL) (Sigma-Aldrich, USA) and epidermal growth factor (EGF) (20 ng/mL) (SigmaAldrich, USA) onto the fibronectin coated TC plates according to the protocol reported by Bondurand et al (8). Because this polymer block is hydrophilic at temperatures below the sol-gel transition temperature (20°C for the TGP used in this study) and hydrophobic at temperatures above this sol-gel transition temperature forming a homogenous three-dimensional (3D) network of the gel in water, cells for culture can be embedded at temperatures lower than 20°C and cultured three dimensionally in the hydrogel state at 37°C.…”

Optoelectronic Heating for Fabricating Microfluidic Circuitry

“…They are typically based on thermal expansion of bubbles or nanocomposite materials in prefabricated areas. Biocompatible thermoreversible gelation polymers offer more flexibility [13]. Those polymers solidify when heated and are biocompatible.…”