A synthetic combination of α-tocopherol with betulonic acid as an example of lupane triterpenoids

Spivak, A. Yu.; Khabibrakhmanova, O. V.; Mufazzalova, R. R.; Odinokov, V. N.; Джемилев, У. М.

doi:10.1134/s0012500808120033

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2010

2023

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Cited by 3 publications

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“…We recently reported on the synthesis of a bioconjugate of α-tocopherol and betulonic acid with a linker of the glycine residue [18]. In this study we obtained the condensation products of triterpene acids with synthetic analogs of α-tocopherol: hydrophilic antioxidant 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-carboxylic acid (Trolox acid) (I), chromanylmethanol (III), and 2-(chromanyl)ethanol (V).…”

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confidence: 99%

Synthesis of triterpene acids conjugates with α-tocopherol synthetic analogs

et al. 2010

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Heterodimers were synthesized of pharmacologically important α-tocopherol synthetic analogs with triterpene acids(betulonic, betulinic), potential polyfunctionsl drugs possessing antioxidant activity. The combination of the fragments of biologically active substances was performed through linkers (residues of succinic acid, hydrazine, glycine, tetramethylenediamine) binding the side chain of the antioxidant molecule with atoms C 3 or C 28 of the terpenoid.

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confidence: 99%