A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance
Xu Wang,
Jin Feng,
Le Zheng
et al.
Abstract:The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. As antibiotic resistance continues to escalate worldwide, the development of new antibiotics that can effectively treat bacterial infections is crucial. Based on this study, we report the development of a hybrid antimicrobial drug that is rationally designed through drug structural hybridization-based structure-guided design and component-based synthesis. The optimal modified co… Show more
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