A synovial sarcoma with t(x;18)(p11;q11) in a patient with turner's syndrome

Abstract

The first case of synovial sarcoma in a patient with Turner's syndrome (45,X) is reported. Cytogenetic analysis of the tumor cells showed that the only X chromosome was involved in the t(X;18)(p11;q11) characteristic of synovial sarcoma.

Leiomyosarcoma of the Oropharynx and Neurogenic Tumors in a Young Patient With Turner′s Syndrome

“…22 Instead, the occurrence of sarcomas in Turner's syndrome is a very rare event with only few published cases. [4][5][6][7][8][9] For the endometrial sarcomas, as already postulated for endometrial carcinomas, 23,24 it has been suggested that the risk may be increased by estrogen replacement therapy or endogenous disorders that lead to unopposed estrogenic stimulation of the uterus. 6,7 This mechanism has also been recalled for LMS of the uterus 25 and oral cavity 26 of patients without Turner's syndrome.…”

Identification of a yeast artificial chromosome (YAC) spanning the synovial sarcoma‐specific t(X;18)(p11.2;q11.2) breakpoint

“…At present, cytogenetic analyses have been carried out on a relatively large number of synovial sarcomas, and a specific chromosomal translocation (X;l8)(pll.Z;qll.Z) alone, or in association with other abnormalities, is consistently observed Turc-Carel et al, 1986Griffin and Emanuel, 1987;Smith et al, 1987;Wang-Wuu et al, 1987;Noguera et al, 1988;Ueda et al, 1988;Marc'Hadour et al, 1991;Miozzo et al, 1992). Due to its specific character, this translocation constitutes a primary cancer-I83 associated abnormality and i:he breakpoint regions are, therefore, of particular interest.…”