A synergistic nanoformulation of babassu and copaiba oils as natural alternative for prevention of benign prostatic hyperplasia

Abreu, Letícia Coli Louvisse de; Furtado, Priscila de Souza; Honorio, Thiago da Silva; Hossy, Bryan Hudson; Pádula, Marcelo de; Domingos, Thaisa Francielle Souza; Carmo, Flávia Almada do; Miguel, Nádia Campos de Oliveira; Rodrigues, Carlos Rangel; Sousa, Valéria Pereira de; Sathler, P.C; Cabral, Lúcio Mendes

doi:10.1016/j.jddst.2018.07.013

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…The construction of the phase diagrams of formulations was carried out in order to evaluate the amount of water to be added to the formulation and then to compare the efficiency of the different components used in terms of this incorporation [12,16,24]. The pseudo-ternary phase diagram was carried out using different weight ratios of the oil phase and surfactants (1:9; 2:8; 3:7; 4:6; 5:5; 6:4; 7:3; 8:2; 9:1).…”

Section: Selection Of Surfactants and Oilsmentioning

confidence: 99%

“…Grade D Dull, greyish-white emulsion having slightly oily appearance that is slow to emulsify (longer than 2 min) Grade E Formulation exhibiting either poor or minimal emulsification with large oil droplets on the surface test was applied. SEDDS formulations were submitted to different thermodynamic stress conditions, including a heating/cooling cycle (45°C and 4°C) and a freeze/thaw cycle, (−21°C and +25°C) with storage at each temperature for not less than 48 h. In addition, centrifugation stress (3000 rpm for 30 min at 25°C) was performed and the extent of phase separation was monitored [16,25]. Stress stability studies were carried out with a SEDDS formulation in a climatic chamber (Nova Ética 420/ CLDTS 300 model, São Paulo, Brazil) at 40 ± 2°C and 75± 5% of relative humidity [26].…”

Section: Grade C Fine Milky Emulsion That Formed Within 2 Minmentioning

confidence: 99%

“…A promising approach is the use of self-emulsifying drug delivery systems (SEDDS) that are composed of an isotropic mixture of oils, surfactants and co-solvents, that form clear and transparent solutions, with the ability to emulsify, forming fine oil emulsions in water when exposed to the aqueous medium under moderate agitation [16][17][18]. The term SEDDS is broad and typically used for formulations that produce emulsions with droplet sizes ranging from a few nanometres to a few micrometres [19].…”

Section: Introductionmentioning

confidence: 99%

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Development of SEDDS formulation containing caffeine for dermal delivery

Almeida

Honorio

Carmo

et al. 2023

Intern J of Cosmetic Sci

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Objective: The objective of this work was to develop a self-emulsifying drug delivery system (SEDDS) containing caffeine for the treatment of cellulite.Methods: SEDDS were prepared using the solution method. 0.5% (w/v) caffeine was added to the previously selected excipients. The system was characterized by droplet size, zeta potential, emulsification time and long-term stability. In vitro release and skin permeation were investigated using Franz-type diffusion cells.The cytotoxicity was evaluated on normal human keratinocytes.Results: Caffeine SEDDS were thermodynamically stable, with a zeta potential less than -22 mV and droplet size around 30 nm, and were long-term stable. The permeation study showed that the formulation promoted caffeine accumulation in the skin layers, suggesting an increase in local circulation. Cytotoxicity studies on HaCaT cells were not conclusive as the surfactant used indicated false-positive results due to its high molar mass. Conclusion:It was possible to obtain a stable SEDDS that could cause an increase in blood flow in the applied area, resulting in cellulite reduction.

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Section: Selection Of Surfactants and Oilsmentioning

confidence: 99%

Section: Grade C Fine Milky Emulsion That Formed Within 2 Minmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of SEDDS formulation containing caffeine for dermal delivery

Almeida

Honorio

Carmo

et al. 2023

Intern J of Cosmetic Sci

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“…The use of copaiba-oil resin (COP) and babassu oil (BBS) and incorporated into self-emulsifying drug delivery systems (SEDDS) [115]. The physical characteristics of the resulting nanoemulsion were next analyzed to identify the preparation suitable for in-vitro toxicity and in-vivo tests.…”

Section: Babassu Oil (Bbs) and Copaiba Oil (Cop) Resinmentioning

confidence: 99%

Exploring Nanoemulsions for Prostate Cancer Therapy

et al. 2021

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Prostate carcinoma is typical cancer. It is the second most common cancer globally. The estimated new cases in 2020 was 191 930 and estimated deaths was 33 330. Age, family history, & genetic factors are major factors that drive prostate cancer. Although, for treating metastatic disease, the major therapies available are radiation,bisphosphonate, and palliative chemotherapy. But the major drawback is therapy is disease-driven and later becomes metastatic and requires treatment. The ability to revolutionize cancer treatment by major targeting vehicles via the exploration of nanoemulsion suggests a potential for cancer treatment. The unique property of a biphasic liquid dosage form called nanoemulsion to reach leaky tumor vasculature is due to its nano-meter oil-droplet size of 20–200 nm. Recent reporting on nanoemulsions disclose their embracing and lay alternative for re-purposing herbal and synthetic drugs and their combination especially for targeting prostate cancer formulating an obtainable nanomedicine. So, this article emphasizes the use of nanoemulsions incorporating therapeutic agents for successful and targeted delivery for prostate cancer.

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“…Since oral administration of sildenafil shows pharmacokinetic disadvantages, many studies with nanoformulations based on nanostructured lipid carriers (NLCs) (Nafee et al 2018), nanoparticles suspensions (Beck-Broichsitter et al 2012), solid lipid nanoparticles (SLN) (Paranjpe et al 2013) have been reported to improve these issues. A promising approach is the use of self-emulsifying drug delivery systems (SEDDS) which have been successfully developed and designed to improve solubility, dissolution, and oral bioavailability of different drugs (Wu et al 2006, Atef & Belmonte 2008, Lu et al 2008, Baek et al 2013, Constantinides 1995, Kommuru et al 2001, Kang et al 2004, de Abreu et al 2018.…”

Section: Introductionmentioning

confidence: 99%

In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension

Abrahim-Vieira

Souza

Barros

et al. 2020

An. Acad. Bras. Ciênc.

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Sildenafi l is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary arterial hypertension treatment. Since oral administration of sildenafi l shows pharmacokinetic problems with mean absolute bioavailability of 41%, the goal of this work was to develop a novel sildenafi l self-emulsifying drug delivery system (SEDDS) for oral absorption improvement and management of dosage. One pharmaceutical solution and four SEDDS containing sildenafi l were successfully obtained and SEDDS formed O/W nanoemulsion with droplet size less than 300 nm. The stability studies evidenced that the SEDDS containing 3.3% w/w of sildenafi l yielded the best results. The safety of 2-pyrrolidone/ isobutanol in oral formulations was assessed in mice and no lethality was achieved in the placebo groups with LD50 of 490 mg/Kg for SEDDS II-3.3, suggesting it as a safe excipient for humans. Therewithal, in silico studies using PBPK models provided the pharmacokinetic profi le of sildenafi l SEDDS. Subsequently, in silico evaluation indicated that the sildenafi l SEDDS droplet size infl uenced its bioavailability, enhancing absorption, assuring a good pharmacokinetic profi le. These fi ndings suggest that the formulations developed here presented the potential to enhance drug oral absorption with the possibility to control drug dosage as they are liquid pharmaceutical formulations.

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A synergistic nanoformulation of babassu and copaiba oils as natural alternative for prevention of benign prostatic hyperplasia

Cited by 9 publications

References 34 publications

Development of SEDDS formulation containing caffeine for dermal delivery

Development of SEDDS formulation containing caffeine for dermal delivery

Exploring Nanoemulsions for Prostate Cancer Therapy

In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension

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