A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis

Ohyama, Kana; Nogusa, Yoshihito; Shinoda, Kosaku; Suzuki, Katsuya; Bannai, Makoto; Kajimura, Shingo

doi:10.2337/db15-0662

Cited by 89 publications

(71 citation statements)

References 56 publications

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“…However, it has recently been found that capsinoids (non-pungent analogues of capsaicin), through an activation of β2-AR, also induce WAT browning and PRDM16 protein stabilization in subcutaneous WAT 104 . It is conceivable that other hormonal stimuli — such as BMP7 (REFS 105,106), a newly identified myokine, irisin 107 , fibroblast growth factor 21 (FGF21) 108,109 and natriuretic peptides 91 — may also induce WAT browning through this mechanism.…”

Section: Regulation By External Cuesmentioning

confidence: 99%

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Inagaki

Sakai

Kajimura

2016

Nat Rev Mol Cell Biol

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268

267

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White adipocytes store excess energy in the form of triglycerides, whereas brown and beige adipocytes dissipate energy in the form of heat. This thermogenic function relies on the activation of brown and beige adipocyte-specific gene programmes that are coordinately regulated by adipose-selective chromatin architectures and by a set of unique transcriptional and epigenetic regulators. A number of transcriptional and epigenetic regulators are also required for promoting beige adipocyte biogenesis in response to various environmental stimuli. A better understanding of the molecular mechanisms governing the generation and function of brown and beige adipocytes is necessary to allow us to control adipose cell fate and stimulate thermogenesis. This may provide a therapeutic approach for the treatment of obesity and obesity-associated diseases, such as type 2 diabetes.

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Section: Regulation By External Cuesmentioning

confidence: 99%

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Inagaki

Sakai

Kajimura

2016

Nat Rev Mol Cell Biol

Self Cite

268

267

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“…Interestingly, capsinoids associated with physical exercise blocked diet‐induced obesity by increasing energy consumption, even though this effect has been attributed to TRPA1 receptor . More recently, a synergistic antiobesity effect by a combination of capsinoids and cold temperature through promoting beige adipocyte biogenesis has been observed …”

Section: Pathophysiological Rolesmentioning

confidence: 99%

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

Tabrizi

Baraldi

et al. 2016

Medicinal Research Reviews

119

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Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory neurons triggering an influx of cations. TRPV1 receptors function as homotetramers responsive to heat, proinflammatory substances, lipoxygenase products, resiniferatoxin, endocannabinoids, protons, and peptide toxins. Its phosphorylation increases sensitivity to both chemical and thermal stimuli, while desensitization involves a calcium-dependent mechanism resulting in receptor dephosphorylation. TRPV1 functions as a sensor of noxious stimuli and may represent a target to avoid pain and injury. TRPV1 activation has been associated to chronic inflammatory pain and peripheral neuropathy. Its expression is also detected in nonneuronal areas such as bladder, lungs, and cochlea where TRPV1 activation is responsible for pathology development of cystitis, asthma, and hearing loss. This review offers a comprehensive overview about TRPV1 receptor in the pathophysiology of chronic pain, epilepsy, cough, bladder disorders, diabetes, obesity, and hearing loss, highlighting how drug development targeting this channel could have a clinical therapeutic potential. Furthermore, it summarizes the advances of medicinal chemistry research leading to the identification of highly selective TRPV1 antagonists and their analysis of structure-activity relationships (SARs) focusing on new strategies to target this channel.

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“…This was confirmed by increased BAT and beige specific gene markers such as Ucp1, Pgc1α, Cidea, Cd137, and Tmem26 , in inguinal WAT, respectively. It has been shown that capsinoids upregulated the expression of the PRDM16 protein in inguinal WAT under ambient and mildly cold temperatures upon β-adrenergic stimulation [95]. Yoneshiro et al demonstrated that acute administration of capsinoids increased energy expenditure in BAT-positive subjects, but not in subjects without metabolically active BAT, under cold exposure [96].…”

Section: Phytochemicals In Obesitymentioning

confidence: 99%

Phytochemicals as novel agents for the induction of browning in white adipose tissue

et al. 2016

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Obesity and its associated metabolic syndrome continue to be a health epidemic in westernized societies and is catching up in the developing world. Despite such increases, little headway has been made to reverse adverse weight gain in the global population. Few medical options exist for the treatment of obesity which points to the necessity for exploration of anti-obesity therapies including pharmaceutical and nutraceutical compounds. Defects in brown adipose tissue, a major energy dissipating organ, has been identified in the obese and is hypothesized to contribute to the overall metabolic deficit observed in obesity. Not surprisingly, considerable attention has been placed on the discovery of methods to activate brown adipose tissue. A variety of plant-derived, natural compounds have shown promise to regulate brown adipose tissue activity and enhance the lipolytic and catabolic potential of white adipose tissue. Through activation of the sympathetic nervous system, thyroid hormone signaling, and transcriptional regulation of metabolism, natural compounds such as capsaicin and resveratrol may provide a relatively safe and effective option to upregulate energy expenditure. Through utilizing the energy dissipating potential of such nutraceutical compounds, the possibility exists to provide a therapeutic solution to correct the energy imbalance that underlines obesity.

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A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis

Cited by 89 publications

References 56 publications

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

Phytochemicals as novel agents for the induction of browning in white adipose tissue

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