A Syndrome Resembling Infectious Mononucleosis After Open-heart Surgery

Smith, Daniel R.

doi:10.1136/bmj.1.5388.945

Cited by 75 publications

(12 citation statements)

References 7 publications

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“…137,138 Patients typically presented with fever, splenomegaly, and atypical lymphocytosis within 3 to 8 weeks of surgery, but had a negative heterophile antibody test and did not experience exudative pharyngitis or lymphadenopathy. 137,138 Patients typically presented with fever, splenomegaly, and atypical lymphocytosis within 3 to 8 weeks of surgery, but had a negative heterophile antibody test and did not experience exudative pharyngitis or lymphadenopathy.…”

Section: Transfusion-transmitted CMV Infectionsmentioning

confidence: 99%

Human Herpesvirus Infections

Roback¹

2007

Blood Banking and Transfusion Medicine

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Section: Transfusion-transmitted CMV Infectionsmentioning

confidence: 99%

Human Herpesvirus Infections

Roback¹

2007

Blood Banking and Transfusion Medicine

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“…Transfusion-transmitted CMV infection, or TT-CMV, was first described in the 1960s in patients transfused during cardiopulmonary bypass for open heart surgery [1,2]. The clinical presentation was suggestive of infectious mononucleosis, with fever, splenomegaly and atypical lymphocytosis, but the heterophile antibody test was negative.…”

Section: Introductionmentioning

confidence: 99%

CMV and blood transfusions

Roback

2002

Reviews in Medical Virology

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Among the human herpesviruses, cytomegalovirus (CMV) is the only one that has assumed significant importance in blood transfusion. Transfusion transmission of CMV (TT-CMV) to seronegative immunocompromised patients can lead to lethal CMV disease. Studies over the past 30 years have demonstrated that monocytes latently infected with CMV represent the primary vector for TT-CMV, and that TT-CMV can be largely abrogated by transfusing at-risk patients with either seronegative units or blood filtered to remove white blood cells. However, the small number of cases of breakthrough TT-CMV that follow transfusion of either seronegative or filtered blood still produce morbidity and mortality. These circumstances have motivated ongoing efforts to provide improved protection from TT-CMV, including the use of CMV DNA amplification for blood screening, and pathogen inactivation to sterilise all blood components prior to transfusion.

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“…Atypical mononuclear cells, which are regarded as DNA-synthesizing blast cells, appear in peripheral blood after other kinds of surgical operation except for allotransplantation (Smith 1964;Codd et al . 1974).…”

Section: Discussionmentioning

confidence: 99%