A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone

Schwartz, William B.; Bennett, Warren A.; Curelop, Sidney; Bartter, Frederic C.

doi:10.1016/0002-9343(57)90224-3

Cited by 1,044 publications

(428 citation statements)

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“…Patient B's symptoms were those of the Schwartz-Bartter Syndrome (Schwartz et al, 1957). Barraclough, Jones and Lee (1966) (Barraclough et al, 1966).…”

Section: Resultsmentioning

confidence: 97%

Ultrastructure of an oat cell carcinoma of the bronchus producing an antidiuretic hormone.

Whitelaw¹

1969

Br J Cancer

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“…Patient B's symptoms were those of the Schwartz-Bartter Syndrome (Schwartz et al, 1957). Barraclough, Jones and Lee (1966) (Barraclough et al, 1966).…”

Section: Resultsmentioning

confidence: 97%

Ultrastructure of an oat cell carcinoma of the bronchus producing an antidiuretic hormone.

Whitelaw¹

1969

Br J Cancer

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“…Initially, hyponatremia in patients with intracranial disease was attributed to cerebral salt wasting syndrome (csWs), as proposed by Peters et al in 1950 13 . later, the syndrome of inappropriate antidiuretic hormone secretion (sIADH), described by schwartz et al in 1957 14 , became accepted as the principal cause of hypona-tremia in neurological patients with excessive urinary sodium loss, and the original concept of csWs was abandoned 1,8,[14][15][16][17] . Hypernatremia is the sodium disturbance least frequently found in these patients and its principal cause is neurogenic diabetes insipidus.…”

mentioning

confidence: 99%

“…csWs and sIADH show very similar laboratory characteristics [13][14][15] and are equally associated with neurological disease. However, they differ with respect to volemic states since sIADH is associated with normovolemia or hypervolemia, whereas csWs is associated with fluid depletion 2,4,5,7 .…”

mentioning

confidence: 99%

Syndromes related to sodium and arginine vasopressin alterations in post-operative neurosurgery

Cardoso

Dragosavac

Araújo

et al. 2007

Arq. Neuro-Psiquiatr.

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-Background: cerebral salt wasting syndrome (csWs), syndrome of inappropriate antidiuretic hormone secretion (sIADH) and diabetes insipidus (DI) are frequently found in postoperative neurosurgery. Purpose: to identify these syndromes following neurosurgery. Method: the study included 30 patients who had been submitted to tumor resection and cerebral aneurysm clipping. sodium levels in serum and urine and urine volume were measured daily up to the 5 th day following surgery. Plasma arginine vasopressin (AVP) was measured on the first, third and fifth days post-surgery. Results: csWs was found in 27/30 patients (90%), in 14 (46.7%) of whom it was associated with a reduction in the levels of plasma AVP (mix syndrome). sIADH was found in 3/30 patients (10%). there was no difference between the two groups of patients. Conclusion: csWs was the most common syndrome found, and in half the cases it was associated with DI. sIADH was the least frequent syndrome found.Key WorDs: cerebral salt wasting syndrome, syndrome of inappropriate antidiuretic hormone secretion, diabetes insipidus, mixed syndrome, neurosurgery.Síndromes relacionadas com alterações de sódio e arginina-vasopressina no pós-operatório de neurocirurgia resUMo -Introdução: A síndrome perdedora de sal (sPs), síndrome da secreção inapropriada do hormô-nio antidiurético (sIADH) e diabetes insipidus (DI) são freqüentemente encontradas no pós-operatório de neurocirurgia. Objetivo: Identificar essas síndromes relacionadas à neurocirurgia. Método: Foram estudados 30 pacientes submetidos à ressecção de tumor (n=19) e clipagem de aneurisma (n=11) cerebral durante os primeiros cinco dias do pós-operatório. os pacientes foram submetidos a dosagens diárias de só-dio sérico e urinário até o 5º dia pós-operatório, com controle de volume urinário neste período e dosagem de arginina-vasopressina (AVP) plasmática no 1º, 3º e 5º dias pós-operatórios. Resultados: A sPs foi encontrada em 27/30 pacientes (90%), em 14/27 (46,7%) associada à diminuição dos níveis de AVP plasmá-tica (síndrome mista). A sIADH foi encontrada em 3/30 pacientes (10%). Não houve diferença entre os dois grupos de pacientes. Conclusão: A sPs foi a síndrome mais freqüente, em metade de casos associada ao DI. A sIADH foi a menos freqüente.PAlAVrAs-cHAVe: síndrome perdedora de sal, síndrome de secreção inapropriada de hormônio antidiurético, diabetes insipidus, síndrome mista, neurocirurgia.

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“…Syndromeof inappropriate secretion of the antidiuretic hormone (SIADH), was first described by Schwartz et al (1) in patients with bronchogenic carcinoma whowere hyponatremic, but clinically euvolemic with normal renal and adrenal function in 1957. Long lists of disorders which can be associated with SIADHwere proposed by many investigators (2-4), but all excluded adrenal insufficiency.…”

mentioning

confidence: 99%

The Role of Antidiuretic Hormone in Hyponatremia in Adrenal Insufficiency-Is the Guideline for the Diagnosis of Syndrome of Inappropriate Secretion of the Antidiuretic Hormone Appropriate?-

Demura

1999

Intern. Med.

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A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone

Cited by 1,044 publications

References 12 publications

Ultrastructure of an oat cell carcinoma of the bronchus producing an antidiuretic hormone.

Ultrastructure of an oat cell carcinoma of the bronchus producing an antidiuretic hormone.

Syndromes related to sodium and arginine vasopressin alterations in post-operative neurosurgery

The Role of Antidiuretic Hormone in Hyponatremia in Adrenal Insufficiency-Is the Guideline for the Diagnosis of Syndrome of Inappropriate Secretion of the Antidiuretic Hormone Appropriate?-

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