A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy. A clinical and histopathological study

Aarnoudse, Jg; Houthoff, H. J.; Weits, J

doi:10.1016/0020-7292(87)90266-9

Cited by 29 publications

(38 citation statements)

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“…The histopathologic abnormalities in HELLP syndrome are periportal and/or focal parenchymal lesions with large fibrin deposits (143). As a result, serum liver enzymes such as aspartate transaminase Corticosteroids, Pregnancy, and HELLP Syndrome Y CME Review Article 63…”

Section: Pathophysiology Of Preeclampsia and The Hellp Syndromementioning

confidence: 99%

Corticosteroids, Pregnancy, and HELLP Syndrome: A Review

Heimel¹,

Franx²,

Schobben³

et al. 2005

Obstetrical & Gynecological Survey

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Corticosteroids are potent antiinflammatory and immunosuppressive drugs, which are used in the treatment of a wide range of medical disorders. During pregnancy, several corticosteroids are administered for maternal as well as fetal reasons. Prednisone and prednisolone show limited transplacental passage and are thus used for treatment of maternal disease. Dexamethasone and betamethasone, drugs that can easily cross the placenta, are more suitable for fetal indications. During the last decade, administration of corticosteroids was introduced in the treatment of hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome), a severe form of preeclampsia unique to human pregnancy. Several randomized, controlled trials as well as other prospective and retrospective studies have been performed to investigate this beneficial effect of corticosteroids on biochemical measures and clinical signs. This review discusses the characteristics of corticosteroids in humans and details the use of corticosteroids during pregnancy. A review of literature on the effect of corticosteroids on HELLP syndrome is given and possible mechanisms of action are discussed.

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Section: Pathophysiology Of Preeclampsia and The Hellp Syndromementioning

confidence: 99%

Corticosteroids, Pregnancy, and HELLP Syndrome: A Review

Heimel¹,

Franx²,

Schobben³

et al. 2005

Obstetrical & Gynecological Survey

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show abstract

“…Epigastric pain occurred in nearly 75% of our HELLP syndrome cases, which is consistent with the higher liver enzymes found in women with HELLP syndrome. Interestingly, Aarnoudse et al 18 found no important differences in the histology of liver biopsy specimens of HELLP syndrome and severe preeclamptic women. This corresponds to our observations with placental histology.…”

Section: Discussionmentioning

confidence: 97%

A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia

Smulian¹,

Shen‐Schwarz

Scorza

et al. 2004

Journal of Maternal-Fetal and Neonatal Medicine

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“…The hepatic abnormalities of HELLP syndrome, a severe manifestation of preeclampsia, consist primarily of periportal and focal parenchymal necrosis [19]. This is most likely the result of hepatic ischemia due to fibrin deposition in the sinusoids.…”

Section: Hepatic Diseasementioning

confidence: 99%

Long-term follow-up after pre-eclampsia/HELLP syndrome

Pampus

2005

International Congress Series

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A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy. A clinical and histopathological study

Cited by 29 publications

References 0 publications

Corticosteroids, Pregnancy, and HELLP Syndrome: A Review

Corticosteroids, Pregnancy, and HELLP Syndrome: A Review

A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia

Long-term follow-up after pre-eclampsia/HELLP syndrome

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