A syndrome first described in 1936, still relevant today

Tourniaire, R.; Rtail, R.; Timi, N; Righini, Christian

doi:10.1016/j.anorl.2010.11.002

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…The role of anticoagulation in patients with Lemierre's syndrome is not well defined (2,10,20,21,22). Theoretically, these patients have a risk of venous septic embolism.…”

Section: Discussionmentioning

confidence: 99%

“…In cases of retrograde extension of thrombus where stroke or pulmonary embolus is a potential risk, anticoagulation is recommended to prevent these complications. A wide range of recommendations regarding anticoagulation has been reported, including no coagulation to extended therapy with warfarin (2,20,21,22). Due to the rarity and heterogeneity of presentations of Lemierre's syndrome, a direct outcome analysis based on anticoagulation therapy alone is difficult (22).…”

Section: Discussionmentioning

confidence: 99%

“…This entity would later become known as Lemierre's syndrome (1). Septicemia was primarily associated with anaerobic oropharyngeal infection extending to the neck, with disseminated, and mostly pulmonary, abscesses (1,2). The mortality rate in Lemierre's series was 90% (1).…”

Section: Introductionmentioning

confidence: 99%

“…The mortality rate in Lemierre's series was 90% (1). The syndrome is usually characterized by a history of recent oropharyngeal infection, clinical or radiologic evidence of internal jugular vein thrombosis, including remote septic emboli, and isolation of anaerobic pathogens-primarily Fusobacterium necrophorum, although other pathogens have been reported (2)(3)(4)(5)(6)(7). Reports of Lemierre's syndrome significantly declined after the discovery and widespread use of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral arterial embolization and limb ischemia complicating septic internal jugular vein thrombosis: a case report of Lemierre’s syndrome

Flis¹,

Borovšak²

2021

AMB

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Purpose: Septic thrombophlebitis of the internal jugular vein is a life-threatening complication of venous thrombosis. While heparin is frequently added to antimicrobial therapy, its usefulness in patients with Lemierre’s syndrome is controversial. In this case report, we demonstrate that delayed use of intravenous heparin may be associated with septic embolization of peripheral arteries. Limb ischemia has rarely been reported in patients with Lemierre’s syndrome. Case presentation: Lemierre’s syndrome is a complex and unusual clinical entity, characterized by septic thrombophlebitis of the internal jugular vein and accompanied by sepsis. We present an unusual case of a young female with Lemierre’s syndrome who developed peripheral arterial embolization and Streptococcus pyogenes sepsis, complicating septic internal jugular vein thrombosis. The patient was initially treated with antibiotics without therapeutic heparin. The patient developed digital gangrene in all four extremities, septic meningitis, and a severe fungal infection; she died 6 weeks after admission secondary to multisystem organ failure. We discuss the importance of rapid diagnosis of disease extent in directing heparin treatment in patients with Lemierre’s syndrome. Conclusion: It may be advisable to treat Lemierre’s syndrome with anticoagulation in the acute setting.

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“…The role of anticoagulation in patients with Lemierre's syndrome is not well defined (2,10,20,21,22). Theoretically, these patients have a risk of venous septic embolism.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral arterial embolization and limb ischemia complicating septic internal jugular vein thrombosis: a case report of Lemierre’s syndrome

Flis¹,

Borovšak²

2021

AMB

View full text Add to dashboard Cite

show abstract

“…(1) Septicemia was mostly associated with anaerobic oropharyngeal infection extending to the neck, with disseminated (mostly pulmonary) abscesses. (1,2) The mortality rate in Lemierre's series was 90%. (1) The syndrome is usually characterized by a history of recent oropharyngeal infection, clinical or radiological evidence of IJVT, including remote septic emboli, and isolation of anaerobic pathogens, mainly Fusobacterium necrophorum, although other pathogens have been reported.…”

Section: Introductionmentioning

confidence: 99%