A synchronous fluorescence spectrofluorometric method for the simultaneous determination of policresulen and cinchocaine hydrochloride in ointment and suppositories

Salem, Hesham; Abdelaziz, Amany; Atef, Arwa; Abdelrady, Rania; Ibrahim, Mohamed A.; El-Kady, Ahmed S.

doi:10.1016/j.saa.2021.119648

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Synchronous fluorescence spectroscopy (SFS) is widely utilized in various fields, including environmental analysis, pharmaceuticals, food science, and biochemistry, as it allows researchers to study the structural changes and interactions of molecules in complex matrices. By exploiting the advantages of SFS, scientists can gain deeper insights into the chemical and biochemical properties of substances, leading to more accurate and comprehensive results [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Fast concurrent determination of guaifenesin and pholcodine in formulations and spiked plasma using first derivative synchronous spectrofluorimetric approach

Roshdy,

Salam,

Hadad

et al. 2024

Luminescence

View full text Add to dashboard Cite

Guaifenesin and pholcodine are frequently co‐formulated in certain dosage forms. A new fast first derivative synchronous spectrofluorometric method has been used for their simultaneous analysis in mixtures. Here, first derivative synchronous spectrofluorometry enabled the successful simultaneous estimation of guaifenesin at 283 nm and pholcodine at 275 nm using a wavelength difference (Δλ) of 40 nm. The method was fully validated following International Council of Harmonization guidelines. For guaifenesin and pholcodine, linearity was determined within the corresponding ranges of 0.05–0.30 and 0.10–6.0 μg/ml. The two drugs were effectively analyzed using the developed approach in their respective formulations, and the results showed good agreement with those attained using reference methods. The method demonstrated excellent sensitivity, with detection limits down to 0.007 and 0.030 μg/ml and quantitation limits of 0.020 and 0.010 μg/ml for guaifenesin and pholcodine, respectively. Therefore, the procedure was successful in determining these drugs simultaneously in vitro in spiked plasma samples and syrup dosage form. The developed methodology also offered an environmentally friendly advantage by utilizing water as the optimal diluting solvent throughout the whole work. Different greenness approaches were investigated to ensure the method’s ecofriendly properties.

show abstract

Section: Introductionmentioning

confidence: 99%