A Synchronized Multi-Unit Wireless Platform for Long-Term Activity Monitoring

Freezing of gait (FOG) is one of the most troublesome symptoms of Parkinson’s disease, affecting more than 50% of patients in advanced stages of the disease. Wearable technology has been widely used for its automatic detection, and some papers have been recently published in the direction of its prediction. Such predictions may be used for the administration of cues, in order to prevent the occurrence of gait freezing. The aim of the present study was to propose a wearable system able to catch the typical degradation of the walking pattern preceding FOG episodes, to achieve reliable FOG prediction using machine learning algorithms and verify whether dopaminergic therapy affects the ability of our system to detect and predict FOG. Methods: A cohort of 11 Parkinson’s disease patients receiving (on) and not receiving (off) dopaminergic therapy was equipped with two inertial sensors placed on each shin, and asked to perform a timed up and go test. We performed a step-to-step segmentation of the angular velocity signals and subsequent feature extraction from both time and frequency domains. We employed a wrapper approach for feature selection and optimized different machine learning classifiers in order to catch FOG and pre-FOG episodes. Results: The implemented FOG detection algorithm achieved excellent performance in a leave-one-subject-out validation, in patients both on and off therapy. As for pre-FOG detection, the implemented classification algorithm achieved 84.1% (85.5%) sensitivity, 85.9% (86.3%) specificity and 85.5% (86.1%) accuracy in leave-one-subject-out validation, in patients on (off) therapy. When the classification model was trained with data from patients on (off) and tested on patients off (on), we found 84.0% (56.6%) sensitivity, 88.3% (92.5%) specificity and 87.4% (86.3%) accuracy. Conclusions: Machine learning models are capable of predicting FOG before its actual occurrence with adequate accuracy. The dopaminergic therapy affects pre-FOG gait patterns, thereby influencing the algorithm’s effectiveness.

Section: Discussionmentioning

confidence: 99%

Prediction of Freezing of Gait in Parkinson’s Disease Using Wearables and Machine Learning

Borzì

Mazzetta

Zampogna

et al. 2021

“…Two exoskeletons, worn on both left and right legs, may provide simultaneous bilateral gait measurement to quantify gait symmetry. Synchronization strategies, such as those developed by Coviello et al [ 21 ], can be used to synchronize the multiple sensing devices and better relate all the measurements. As such, the use of the exoskeleton system may potentially expand beyond the prosthesis control application and provide gait measurement for individuals suffering from other mobility-related pathologies such as Parkinson’s Disease.…”

Section: Discussionmentioning

confidence: 99%

A Lightweight Exoskeleton-Based Portable Gait Data Collection System

Haque

Imtiaz

Kwak

et al. 2021

For the controller of wearable lower-limb assistive devices, quantitative understanding of human locomotion serves as the basis for human motion intent recognition and joint-level motion control. Traditionally, the required gait data are obtained in gait research laboratories, utilizing marker-based optical motion capture systems. Despite the high accuracy of measurement, marker-based systems are largely limited to laboratory environments, making it nearly impossible to collect the desired gait data in real-world daily-living scenarios. To address this problem, the authors propose a novel exoskeleton-based gait data collection system, which provides the capability of conducting independent measurement of lower limb movement without the need for stationary instrumentation. The basis of the system is a lightweight exoskeleton with articulated knee and ankle joints. To minimize the interference to a wearer’s natural lower-limb movement, a unique two-degrees-of-freedom joint design is incorporated, integrating a primary degree of freedom for joint motion measurement with a passive degree of freedom to allow natural joint movement and improve the comfort of use. In addition to the joint-embedded goniometers, the exoskeleton also features multiple positions for the mounting of inertia measurement units (IMUs) as well as foot-plate-embedded force sensing resistors to measure the foot plantar pressure. All sensor signals are routed to a microcontroller for data logging and storage. To validate the exoskeleton-provided joint angle measurement, a comparison study on three healthy participants was conducted, which involves locomotion experiments in various modes, including overground walking, treadmill walking, and sit-to-stand and stand-to-sit transitions. Joint angle trajectories measured with an eight-camera motion capture system served as the benchmark for comparison. Experimental results indicate that the exoskeleton-measured joint angle trajectories closely match those obtained through the optical motion capture system in all modes of locomotion (correlation coefficients of 0.97 and 0.96 for knee and ankle measurements, respectively), clearly demonstrating the accuracy and reliability of the proposed gait measurement system.

“…The slaves were synchronized via Bluetooth with the master, which also received a 3 V trigger edge signal. Master/slave architectures are commonly used to ensure synchronicity across sensor units [ 17 ]. The treadmill and master IMU were triggered simultaneously to ensure synchronicity across the systems.…”

Section: Methodsmentioning

confidence: 99%

Deep Convolutional and LSTM Networks on Multi-Channel Time Series Data for Gait Phase Recognition

Kreuzer

Münz

2021

With an ageing society comes the increased prevalence of gait disorders. The restriction of mobility leads to a considerable reduction in the quality of life, because associated falls increase morbidity and mortality. Consideration of gait analysis data often alters surgical recommendations. For that reason, the early and systematic diagnostic treatment of gait disorders can spare a lot of suffering. As modern gait analysis systems are, in most cases, still very costly, many patients are not privileged enough to have access to comparable therapies. Low-cost systems such as inertial measurement units (IMUs) still pose major challenges, but offer possibilities for automatic real-time motion analysis. In this paper, we present a new approach to reliably detect human gait phases, using IMUs and machine learning methods. This approach should form the foundation of a new medical device to be used for gait analysis. A model is presented combining deep 2D-convolutional and LSTM networks to perform a classification task; it predicts the current gait phase with an accuracy of over 92% on an unseen subject, differentiating between five different phases. In the course of the paper, different approaches to optimize the performance of the model are presented and evaluated.