A SWOT analysis of nano co-crystals in drug delivery: present outlook and future perspectives

Witika, Bwalya A.; Choonara, Yahya E.; Demana, Patrick H.

doi:10.1039/d3ra00161j

Cited by 2 publications

(1 citation statement)

References 133 publications

(267 reference statements)

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“…In addition, silver (Ag) nanoparticles were synthesized from cotton fabrics and exhibited strong inhibition activity against some bacteria [ 21 ]. Recently, pure active pharmaceutical ingredient (API) composed of nanocrystals was investigated, as opposed to drug nanocarrier platforms [ 22 ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

Tsai,

Shih,

Tsai

et al. 2024

Beilstein J. Nanotechnol.

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ᴅ-cycloserine (DCS), an FDA-approved medicine for the treatment of tuberculosis, is also a partial agonist at the glycine recognition site of N-methyl-ᴅ-aspartate (NMDA) receptor and has shown significant treatment efficacy for central nervous system (CNS) disorders including depression, schizophrenia, Alzheimer’s disease, and post-traumatic stress disorder. The physicochemical properties of DCS, however, limit the options of formulation and medicinal applications of DCS, and warrants further investigation for the development of CNS therapeutics. Nanocrystals play an important role in pharmaceutic design and development. The properties of nanocrystals are remarkably different from their bulk material counterpart, attributed to the large surface-area-to-volume ratio which can improve the bioavailability. In this study, for the first time, DCS, a highly water-soluble compound, has formed nanocrystals and this was confirmed by scanning electronic microscopy and X-ray powder diffraction. Furthermore, DCS nanocrystals were applied to several formulations to test their stability and then to the in vitro Franz diffusion test with reservoir patch formulation as well as in vivo pharmacokinetics study with enteric capsules. We tested these formulations regarding their nanocrystal physical properties, size effect, and dissolution rate, respectively. We found that DCS nanocrystals showed good performance in the Franz diffusion test and rodent pharmacokinetic studies due to the nanoparticle size and faster dissolution as compared with the commercial DCS powder. These DCS nanocrystal formulations could offer a new approach for the development of an advanced drug delivery system for the treatment of CNS disorders.

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Section: Introductionmentioning

confidence: 99%

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

Tsai,

Shih,

Tsai

et al. 2024

Beilstein J. Nanotechnol.

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Transforming Healthcare with Nanomedicine: A SWOT Analysis of Drug Delivery Innovation

Zhang,

Li,

2024

DDDT

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A SWOT analysis of nano co-crystals in drug delivery: present outlook and future perspectives

Abstract: The formulation of poorly soluble drugs is an intractable challenge in the field of drug design, development and delivery.

Cited by 2 publications

References 133 publications

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

Transforming Healthcare with Nanomedicine: A SWOT Analysis of Drug Delivery Innovation

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