A swiss family with hemoglobin P Galveston 61-161-161-1, including two patients with Hb P/β thalassemia

Abstract

The mutant Hb P Galveston (beta117His leads to Arg) is observed in two heterozygotes for beta thalassemia and by itself does not cause clinical symptoms. Some of the physico-chemical properties of Hb P Galveston are identical to the onemical properties of Hb P Galveston are identical to the ones hemoglobin Zurich (beta 63 His leads to Arg) so that only a detailed analysis led to its proper identification.

Hb Murcia (β118(G19)His>Gln): A New Hemoglobin Variant Found in a Spanish Woman

“…The remaining variants, including the one reported here (Hb Murcia), have not been studied for functionality and stability. However, given the hematological profiles of the patients, both the stability and the functionality of hemoglobin are probably not altered and, therefore, these variants are not harmful, i.e., they are clinically silent [ 3 , 6 - 8 ].…”