A Swedish Foetal Haemoglobin Variant

Abstract

Summary The infant boy of a Swedish woman with the haemoglobin variant Hb Uppsala, was studied during his first six months of life. In cord blood, two major haemoglobin fractions were seen at electrophoresis. One behaved like normal foetal haemoglobin and the other migrated faster than Hb A but slower than Hb Uppsala. When the boy was three months old, this unknown fraction had disappeared and Hb Uppsala was found. Since the abnormality of Hb Uppsala is known to be located in the α‐chain, the unknown fraction was considered to be the foetal type of Hb Uppsala.

Screening for Haemoglobin and Lactate Dehydrogenase Variants in the Icelandic, Swedish, Finnish, Lappish, Mari and Greenland Eskimo Populations

“…[3] described a Hb variant, Hb Uppsala, which was detected during a survey for electrophoretic lactate dehydrogenase (LDH) variants in a sample consisting of 411 Swedish blood donors. Hb Uppsala was also found in a fetal form [21]. The structure of Hb Uppsala was shown to be a 2 54 Gln ►Glu ^ [g], Svensson and Strand [26] reported a new Swedish Hb variant.…”