A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy

Hou, Bo; Yi, Luying; Hu, Dehong; Luo, Zichao; Gao, Duyang; Li, Chao; Xing, Bowen; Wang, Jiong‐Wei; Lee, Chuen Neng; Zhang, Rong; Sheng, Zonghai; Zhou, Bin; Liu, Xiaogang

doi:10.1038/s41551-023-01024-2

Cited by 26 publications

(13 citation statements)

References 43 publications

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“…Hou et al reported a swallowable X-ray dosimeter (containing an optical fiber) for the simultaneous real-time monitoring of the absolute absorbed radiation dose and the changes in pH and temperature. 186 Ran et al utilized functional optical fibers to realize an in vivo endoscopic cancer sensing and therapy ensemble. 187 The above examples provide a solution for the diagnosis and treatment of intracavitary diseases with light-driven MNMs.…”

Section: Current Challengesmentioning

confidence: 99%

Light-driven micro/nanomotors in biomedical applications

Zeng,

Yang,

Liu

et al. 2023

Nanoscale

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Section: Current Challengesmentioning

confidence: 99%

Light-driven micro/nanomotors in biomedical applications

Zeng,

Yang,

Liu

et al. 2023

Nanoscale

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“…52 Most activatable afterglow probes are based on the afterglow resonance energy transfer (ARET) strategy (Table S1), which regulates luminescence solely by tuning the energy acceptor, resulting in a narrow responsive dynamic range. 30,45,53 As for fluorescence, the single regulation of the S 1 −S 0 transition contributes to the "turn-on" emission of fluorescence. In contrast, the regulation site in our afterglow molecular scaffold can simultaneously control the "OFF-ON" switch of the photodynamic effect (transition from S 1 to T 1 ) and luminescence efficacy (transition from S 1 to S 0 ).…”

Section: Design Of Novel Molecular Afterglow Scaffold and The Study O...mentioning

confidence: 99%

Noninvasive Imaging of Tumor Glycolysis and Chemotherapeutic Resistance via De Novo Design of Molecular Afterglow Scaffold

Lei,

Yang,

Meng

et al. 2023

J. Am. Chem. Soc.

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Chemotherapeutic resistance poses a significant challenge in cancer treatment, resulting in the reduced efficacy of standard chemotherapeutic agents. Abnormal metabolism, particularly increased anaerobic glycolysis, has been identified as a major contributing factor to chemotherapeutic resistance. To address this issue, noninvasive imaging techniques capable of visualizing tumor glycolysis are crucial. However, the currently available methods (such as PET, MRI, and fluorescence) possess limitations in terms of sensitivity, safety, dynamic imaging capability, and autofluorescence. Here, we present the de novo design of a unique afterglow molecular scaffold based on hemicyanine and rhodamine dyes, which holds promise for low-background optical imaging. In contrast to previous designs, this scaffold exhibits responsive "OFF-ON" afterglow signals through spirocyclization, thus enabling simultaneous control of photodynamic effects and luminescence efficacy. This leads to a larger dynamic range, broader detection range, higher signal enhancement ratio, and higher sensitivity. Furthermore, the integration of multiple functionalities simplifies probe design, eliminates the need for spectral overlap, and enhances reliability. Moreover, we have expanded the applications of this afterglow molecular scaffold by developing various probes for different molecular targets. Notably, we developed a water-soluble pH-responsive afterglow nanoprobe for visualizing glycolysis in living mice. This nanoprobe monitors the effects of glycolytic inhibitors or oxidative phosphorylation inhibitors on tumor glycolysis, providing a valuable tool for evaluating the tumor cell sensitivity to these inhibitors. Therefore, the new afterglow molecular scaffold presents a promising approach for understanding tumor metabolism, monitoring chemotherapeutic resistance, and guiding precision medicine in the future.

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“…The detection of X-ray doses has become a crucial research area, − given the wide range of applications for X-rays in industries such as nuclear industry, , medical diagnosis, , industrial material inspection, , and security checks. , Traditional X-ray dose detection methods rely on devices like thermoluminescent dosimeters, − ionization chambers, , and semiconductor detectors, − which require complex readout instruments to convert X-ray energy into electrical signals. − This approach has led to expensive, time-consuming, and unsuitable on-site real-time dose assessment. , In contrast, photochromic materials capable of direct “visualization” under X-ray irradiation offer a direct and visual means of dose assessment, facilitating real-time evaluation of radiation exposure. Consequently, these intelligent visual materials hold considerable promise in the development of easy and portable systems for the elucidation of X-ray presence in visual inspection setups. − …”

mentioning

confidence: 99%

Visualized X-ray Dosimetry for Multienvironment Applications

Lu,

Peng,

Zhao

et al. 2023

Nano Lett.

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X-ray dose detection plays a critical role in various scientific fields, including chemistry, materials, and medicine. However, the current materials used for this purpose face challenges in both immediate and delayed radiation detections. Here, we present a visual X-ray dosimetry method for multienvironment applications, utilizing NaLuF 4 nanocrystals (NCs) that undergo a color change from green to red upon X-ray irradiation. By adjustment of the concentrations of Ho 3+ , the emission color of the NCs can be tuned thanks to the cross-relaxation effects. Furthermore, Xray irradiation induces generation of trapping centers in NaLuF 4 :Ho 3+ NCs, endowing the generation of mechanoluminescence (ML) behavior upon mechanical stimulation after X-ray irradiation ceases. The ML intensity shows a linear correlation with the Xray dose, facilitating the detection of delayed radiation. This breakthrough facilitates X-ray dose inspection in flaw detection, nuclear medicine, customs, and civil protection, thereby enhancing opportunities for radiation monitoring and control.

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A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy

Cited by 26 publications

References 43 publications

Light-driven micro/nanomotors in biomedical applications

Light-driven micro/nanomotors in biomedical applications

Noninvasive Imaging of Tumor Glycolysis and Chemotherapeutic Resistance via De Novo Design of Molecular Afterglow Scaffold

Visualized X-ray Dosimetry for Multienvironment Applications

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