A sustained zero-order release carrier for long-acting, peakless basal insulin therapy

Wang, Qianqian; Fu, Mian; Wang, Zuwei; Zhu, Jiale; Guan, Ying; Zhang, Yongjun

doi:10.1039/c9tb02728a

Cited by 16 publications

(9 citation statements)

References 43 publications

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“…Hollow capsules fabricated via LbL assembly of polymers comprise an ultrathin permeable shell (<50 nm) that participates in various types of interactions (Mathivanan et al, 2019 ; Wang et al, 2020 ) and microsized or nanosized cavities that deposit drugs or active molecules. The shells are able to trigger the release of loaded molecules to protect the load from external stress and thus extend the time of release.…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

“…To achieve a persistent, flat, and stable insulin supply, a new drug carrier was designed. Wang et al ( 2020 ) assembled PEG–insulin and TA into a film, which can release PEG–insulin into the medium through a reversible, dynamic hydrogen bond. In addition, the unique release mechanism of the films explained the unique release kinetics of PEG–insulin, which had zero-order kinetics.…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

“…Of note, the thickness of the film is closely related to the reaction time. Their work was promising in the treatment of diabetes, as shown in Figure 13A (Wang et al, 2020 ). Zhu et al ( 2019 ) constructed a novel multifunctional thin-film nanofibrous composite membrane based on TA and polyvinyl alcohol (PSBMA) on TFNC membrane surfaces by LbL assembly, expecting to achieve the filtration of dye and protein.…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

“… Coating films based on TA and their application. (A) The interaction of PEG–insulin and TA was driven by hydrogen bonding, and gradual disintegration of the PEG–insulin/TA LbL film led to the release of PEG–insulin (Wang et al, 2020 ). (B) (a) The preparation and application of the TA-coated gauze in bleeding control [SEM images of the gauze deposited with 0 (b), 1 (c), 3 (d), and 5 (e) TA deposition cycles] (Song et al, 2019 ).…”

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

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Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Zhang

Cheng

et al. 2020

Front. Chem.

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Polyphenol, characterized by various phenolic rings in the chemical structure and an abundance in nature, can be extracted from vegetables, grains, chocolates, fruits, tea, legumes, and seeds, among other sources. Tannic acid (TA), a classical polyphenol with a specific chemical structure, has been widely used in biomedicine because of its outstanding biocompatibility and antibacterial and antioxidant properties. TA has tunable interactions with various materials that are widely distributed in the body, such as proteins, polysaccharides, and glycoproteins, through multimodes including hydrogen bonding, hydrophobic interactions, and charge interactions, assisting TA as important building blocks in the supramolecular self-assembled materials. This review summarizes the recent immense progress in supramolecular self-assembled materials using TA as building blocks to generate different materials such as hydrogels, nanoparticles/microparticles, hollow capsules, and coating films, with enormous potential medical applications including drug delivery, tumor diagnosis and treatment, bone tissue engineering, biofunctional membrane material, and the treatment of certain diseases. Furthermore, we discuss the challenges and developmental prospects of supramolecular self-assembly nanomaterials based on TA.

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Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

Section: Medical Applications Of Ta Self-assemblymentioning

confidence: 99%

See 2 more Smart Citations

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Zhang

Cheng

et al. 2020

Front. Chem.

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“…[21][22][23] When these films are fabricated from monodisperse polymers, zero-order release can be achieved. [24][25][26][27][28][29] Using this principle, dynamic LBL films of PEGylated leuprolide (PEG-LEU) and tannic acid (TA) were fabricated using dynamic hydrogen bonding as the driving force. Both in vitro and in vivo tests revealed that drug release from the film followed perfect zero-order kinetics.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen‐Bonded Films for Zero‐Order Release of Leuprolide

Zhuang²,

Zhang³

et al. 2020

Macromolecular Bioscience

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Leuprolide has been widely used in androgen deprivation therapy for the treatment of advanced prostate cancer, but its use is still limited due to its short half‐life. Herein, hydrogen‐bonded layer‐by‐layer films are fabricated from PEGylated leuprolide (PEG‐LEU) and tannic acid (TA). Because of its dynamic nature, the film disintegrates gradually in water and releases PEG‐LEU and TA. The in vitro release profile indicated perfect zero‐order kinetics, which is explained by the unique release mechanism. When implanted subcutaneously in male rats, the films maintain a constant serum drug level. For a 60‐bilayer film, the serum drug level is maintained constant for ≈24 days. No initial burst release is observed, suggesting that the in vivo release also follows zero‐order kinetics. Initially, an increase in the level of serum testosterone is induced by the released drug, followed by testosterone suppression to a constant level below the castrate level, which could be maintained as long as a constant serum drug level is maintained. Since the new drug carriers avoid an initial burst release of the drug and maintain a constant serum drug level and hence a constant serum testosterone level below the castrate level, these carriers are highly promising for androgen deprivation therapy.

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Long‐Acting Insulin‐Zwitterionic Polymer Conjugate Mitigates Hypoglycemia

Zeng

Hou

et al. 2023

Chemistry A European J

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Insulin, a main medication to control glycemia of type 1 and advanced type 2 diabetes, faces problems of a short half‐life and poor stability during its clinical use. Zwitterionic polymer shows unique properties of antifouling and low immunogenicity. Here, we have synthesized a new insulin‐zwitterionic polymer conjugate (INS‐PMPC) through grafting‐from strategy by controlled radical polymerization. Apart from showing excellent stability upon mechanical agitation, the resulting INS‐PMPC conjugate provided over 20 h of glycemic control due to improved pharmacokinetics in diabetic mice with one single subcutaneous injection. Most importantly, this insulin‐zwitterionic polymer conjugate significantly decreases the incidence of hypoglycemia.

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A sustained zero-order release carrier for long-acting, peakless basal insulin therapy

Abstract: A new drug carrier, which mimics physiologic basal insulin, and secretes and releases insulin at a constant rate, was designed.

Cited by 16 publications

References 43 publications

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Medical Applications Based on Supramolecular Self-Assembled Materials From Tannic Acid

Hydrogen‐Bonded Films for Zero‐Order Release of Leuprolide

Long‐Acting Insulin‐Zwitterionic Polymer Conjugate Mitigates Hypoglycemia

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