A suspected case of both bisphosphonate-related osteonecrosis of the maxilla and methotrexate-associated lymphoproliferative disorder

Intraoral localized methotrexate‐associated lymphoproliferative disorders concurrent with antiresorptive agent‐related osteonecrosis of the jaw: A case report and literature review

“…A review of the literature revealed 22 cases of intraoral localized MTX-LPD with bone exposure, including our case (Table 1). 2,3,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The mean age of the patients was 73 years (range, 44-92 years), and the male to female ratio was 2:1. The mean duration of MTX treatment was 8.6 years (range, 0.6-20 years).…”

“…Most intraoral localized MTX‐LPD patients (20/22) were Japanese 3,20‐30,33,35 . However, the reason is unclear.…”

“…Most intraoral localized MTX-LPD patients (20/22) were Japanese. 3,[20][21][22][23][24][25][26][27][28][29][30]33,35 However, the reason is unclear. Therefore, a study has been initiated jointly by three academic societies (Japan College of Rheumatology, The Japanese Society of Hematology, The Japanese Society of Pathology) in Japan.…”