A Survival Analysis with Identification of Prognostic Factors in a Series of 110 Patients with Newly Diagnosed Glioblastoma Before and After Introduction of the Stupp Regimen: A Single-Center Observational Study

Illic, Rosanda; Somma, Teresa; Savić, Dragan; Frio, Federico; Milićević, M; Solari, Domenico; Nikitović, Marina; Lavrnić, Slobodan; Raicevic, Savo; Milošević, Snežana; Cavallo, Luigi Maria; Cappabianca, Paolo; Grujičić, Danica

doi:10.1016/j.wneu.2017.05.018

Cited by 18 publications

(17 citation statements)

References 33 publications

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“…The treatment rates increased over time. An observation in our data was that patients with lower performance status according to Karnofsky seemed less likely both to start and complete treatment according to Stupp, which is consistent with clinical practice and studies …”

Section: Discussionsupporting

confidence: 90%

Improved survival of Swedish glioblastoma patients treated according to Stupp

et al. 2018

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Section: Discussionsupporting

confidence: 90%

Improved survival of Swedish glioblastoma patients treated according to Stupp

et al. 2018

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“…Univariate analyses showed statistically significant improvement in overall survival of patients younger than 50 years (median survival 19 months) in comparison with the group of patients older than 50 years (median survival 7 months) (p < 0.00045) ( Table 3). This result is in agreement with previous findings that overall survival is significantly higher for younger groups of patients (<50) in comparison with older groups (>50) [19,[24][25][26]. Disruption of the DNA methylation mechanism is associated with aging and is characterized by genome-wide hypomethylation and promoter specific methylation [26][27][28].…”

Section: Patients' Age and Overall Survivalsupporting

confidence: 93%

“…The MGMT DNA repair enzyme counteracts the cytotoxic effect of DNA alkylating agents such as TMZ and mediates chemoresistance. The introduction of TMZ treatment and Stupp regimen in Serbia significantly improved the survival rates of glioblastoma patients [19][20][21]. The survival outcome of the diffuse glioma patients from Serbia included in this study was not correlated with MGMT promoter methylation, which corresponds with findings from a recent study dealing with GBM patients in Serbia [19].…”

Section: Mgmt Status and Overall Survivalsupporting

confidence: 77%

“…Our study confirmed the widely recognized correlation between the extent of the tumour resection and overall survival ( Table 3 and Figure 3). The group of patients with total lesion resection had better overall survival in comparison to those with partial resection and biopsy, thus confirming the survival advantage of complete resection and its cytoreductive effects [19,29].…”

Section: Extent Of Tumour Resection and Overall Survivalmentioning

confidence: 61%

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Prognostic significance of MGMT promoter methylation in diffuse glioma patients

Jovanović

Mitrović

Cvetković

et al. 2019

Biotechnology & Biotechnological Equipment

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Current treatment options for diffuse glioma patients include maximum safe resection followed by a combination of radiation therapy and chemotherapy with alkylating agents. The DNA-repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) counteracts the cytotoxic effect of alkylating agents and mediates chemoresistance. Disruption of the DNA methylation mechanism in diffuse glioma cells results in epigenetic silencing of MGMT through methylation of cytidinephosphate-guanosine dinucleotides (CpG) in the promoter region. The methylation status of MGMT is widely accepted to be a strong prognostic factor in diffuse glioma patients. This study was designed to screen Serbian diffuse glioma patients for hypermethylation of the MGMT promoter and to estimate its impact on overall survival. The results obtained in our study on 33 samples of diffuse glioma detected a positive methylation status in 17 patients (51.5%) by methylation-specific polymerase chain reaction. The positive methylation status of the MGMT promoter did not correlate with overall survival. In this study group, the patients older than 50 years had significantly lower overall survival in comparison with younger patients (7 months-19 months median survival). Extent of tumour resection also had influence on overall survival of patients. The relevance of the MGMT promoter methylation status should be further evaluated in a larger study and in association with other markers. ARTICLE HISTORY

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“…Firstly, the data came from several databases with limited sample size. Secondly, the prognostic factors in the nomogram did not contain the extent of GBM surgical resection which is a cardinal factor associated with GBM prognosis . Therefore, more samples with detailed clinical information will be collected to make up for these shortcomings and assess the efficiency of the nomogram in future study.…”

Section: Discussionmentioning

confidence: 99%

A risk signature with four autophagy‐related genes for predicting survival of glioblastoma multiforme

Wang

Zhao

Xiao

et al. 2020

J Cellular Molecular Medi

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Glioblastoma multiforme (GBM) is a devastating brain tumour without effective treatment. Recent studies have shown that autophagy is a promising therapeutic strategy for GBM. Therefore, it is necessary to identify novel biomarkers associated with autophagy in GBM. In this study, we downloaded autophagy-related genes from Human Autophagy Database (HADb) and Gene Set Enrichment Analysis (GSEA) website. Least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression analysis were performed to identify genes for constructing a risk signature. A nomogram was developed by integrating the risk signature with clinicopathological factors. Time-dependent receiver operating characteristic (ROC) curve and calibration plot were used to evaluate the efficiency of the prognostic model. Finally, four autophagy-related genes (DIRAS3, LGALS8, MAPK8 and STAM)were identified and were used for constructing a risk signature, which proved to be an independent risk factor for GBM patients. Furthermore, a nomogram was developed based on the risk signature and clinicopathological factors (IDH1 status, age and history of radiotherapy or chemotherapy). ROC curve and calibration plot suggested the nomogram could accurately predict 1-, 3-and 5-year survival rate of GBM patients.For function analysis, the risk signature was associated with apoptosis, necrosis, immunity, inflammation response and MAPK signalling pathway. In conclusion, the risk signature with 4 autophagy-related genes could serve as an independent prognostic factor for GBM patients. Moreover, we developed a nomogram based on the risk signature and clinical traits which was validated to perform better for predicting 1-, 3-and 5-year survival rate of GBM. K E Y W O R D Sautophagy, glioblastoma multiform, nomogram, prognosis, risk signature

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A Survival Analysis with Identification of Prognostic Factors in a Series of 110 Patients with Newly Diagnosed Glioblastoma Before and After Introduction of the Stupp Regimen: A Single-Center Observational Study

Abstract: Adoption of the Stupp protocol had a favorable impact on overall, but not on progression-free, survival rate. Wider surgical resection involving the peritumoral brain zone, as confirmed by univariate and multivariate analysis, represents the most favorable prognostic factor.

Cited by 18 publications

References 33 publications

Improved survival of Swedish glioblastoma patients treated according to Stupp

Improved survival of Swedish glioblastoma patients treated according to Stupp

Prognostic significance of MGMT promoter methylation in diffuse glioma patients

A risk signature with four autophagy‐related genes for predicting survival of glioblastoma multiforme

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