A survival analysis approach for identifying the risk factors in time to recovery of COVID-19 patients using Cox proportional hazard model

Das, Dhruba; Saikia, Hemanta; Bora, Dibyajyoti; Bhattacharjee, Dibyojyoti; Das, Jondeep

doi:10.1016/j.dajour.2022.100137

Cited by 1 publication

(1 citation statement)

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“…The performance of each RAT kit was evaluated by estimating precision and recall against the rRT-PCR results using the caret package [ 23 ]. The correlation between the Ct values from rRT-PCR and the results of assays using each RAT kit was evaluated using the log-rank test in the survminer package [ 24 ]. The receiver operating characteristic (ROC) curve and area under curve (AUC) were generated using the pROC package, and the optimal cutoffs for each RAT were calculated using scores that estimated the minimum distance between the left-upper corner and ROC curve [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs

Lim

Park²,

Baek³

et al. 2023

Biomedicines

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Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the capacity of testing systems based on the gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contribute to the prevention of community transmission, but their further assessment is required. Here, using 1503 nasopharyngeal swabs, we compared the diagnostic performance of four RAT kits (Abbott Panbio™ COVID-19 Ag Rapid Test, SD Biosensor Standard™ Q COVID-19 Ag Test, Humasis COVID-19 Ag Test, and SG Medical Acrosis COVID-19 Ag Test) to the cycle threshold (Ct) values obtained from rRT-PCR. The precision values, area under the curve values, SARS-CoV-2 variant detection ability, and non-SARS-CoV-2 specificity of all four kits were similar. An assay using the Acrosis kit had a significantly better positive detection rate with a higher recall value and cut-off value than that using the other three RAT kits. During the current COVID-19 pandemic, the Acrosis kit is an effective tool to prevent the spread of SARS-CoV-2 in communities.

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Section: Methodsmentioning

confidence: 99%