A Survey on the Prevalence of Chlamydia Trachomatis and Mycoplasma Genitalium Infections in Symptomatic and Asymptomatic Men Referring to Urology Clinic of Labbafinejad Hospital, Tehran, Iran

Yeganeh, Omid; Jeddi-Tehrani, Mahmood; Yaghmaie, Farhad; Kamali, Koorosh; Heidari-Vala, Hamed; Zeraati, Hojjat; Shakhssalim, Nasser; Zarei, Sadegh; Chamani-Tabriz, Leili

doi:10.5812/ircmj.8600

Cited by 16 publications

(16 citation statements)

References 23 publications

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“…The prevalence of M. genitalium was 12% and 2% in symptomatic and asymptomatic men, respectively, and M. genitalium infection was associated with dysuria, testis inflammation, pelvic pain, and low educational level [4]. In Mirnejad et al's [20] study, genital swabs were taken from 210 women in Tehran, Iran, and, using PCR the frequency of M. genitalium was 3.3%.…”

Section: Discussionmentioning

confidence: 99%

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A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction

Ramazanzadeh

Khodabandehloo

Farhadifar

et al. 2016

Osong Public Health and Research Perspectives

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ObjectivesMycoplasma genitalium infections are suggested as causes of a number of pathological outcomes in pregnant women. The aim of this study was to evaluate the frequency of M. genitalium infections among pregnant women and its association with spontaneous abortion.MethodsIn this case–control study we included 109 women with spontaneous abortion with a gestational age of 10–20 weeks (patients), and 109 women with normal pregnancy with a gestational age of 20–37 weeks (controls) in Sanandaj, Iran. Using specific primers and extracted DNA from endocervical swabs, a polymerase chain reaction was conducted for the detection of M. genitalium infection in both groups.ResultsThe frequency of M. genitalium infection in patient and control groups was one (0.91%) and three (2.75%), respectively. In both control and patient groups using Fisher test, no association between mycoplasma infection and spontaneous abortion was seen.ConclusionM. genitalium may be positive in the genital tract of some pregnant women but was not associated with spontaneous abortion. Further powerful studies with larger sample sizes are needed for the determination of a possible role of M. genitalium in pregnancy outcomes and spontaneous abortion.

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Section: Discussionmentioning

confidence: 99%

“…are causes of sexually transmitted diseases (STDs) in men and women worldwide. About 80% of infected women and 50% of infected men may be asymptomatic [4]. M. genitalium and M. hominis are suggested as causes of a number of pathological outcomes in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction

Ramazanzadeh

Khodabandehloo

Farhadifar

et al. 2016

Osong Public Health and Research Perspectives

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“…Ali and Al-Kazaz (2018) 85 Abusarah et al (2013) 92 Awwad et al (2003) 95 Yeganeh et al (2013) 77 Meidani (2009) 68 Ahmadi et al (2018) 49 Al-Sweih et al (2012) 100 Mir et al (2009) 108 Total Random-effects model Heterogeneity: I 2 =85%; (p<0•0001)…”

Section: Menmentioning

confidence: 99%

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Smolak

Chemaitelly

Hermez

et al. 2019

The Lancet Global Health

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Background The epidemiology of Chlamydia trachomatis in the Middle East and north Africa is poorly understood. We aimed to provide a comprehensive epidemiological assessment of C trachomatis infection in the Middle East and north Africa. Methods We did a systematic review of C trachomatis infection as well as a meta-analysis and meta-regression of C trachomatis prevalence. We searched PubMed and Embase, as well as regional and national databases up to March 13, 2019, using broad search terms with no language or year restrictions. Any document or report including biological measures for C trachomatis prevalence or incidence was eligible for inclusion. We extracted all measures of current (genital or rectal), recent, and ever infection with C trachomatis. We estimated pooled average prevalence in different populations using random-effects meta-analysis. Factors associated with prevalence and sources of betweenstudy heterogeneity were determined using meta-regression. Findings We identified a total of 1531 citations, of which 255 reports contributed to 552 C trachomatis prevalence measures from 20 countries. No incidence measures were identified. Pooled prevalence of current genital infection was 3•0% (95% CI 2•3-3•8) in general populations, 2•8% (1•0-5•2) in intermediate-risk populations, 13•2% (7•2-20•7) in female sex workers, 11•3% (9•0-13•7) in infertility clinic attendees, 12•4% (7•9-17•7) in women with miscarriage, 12•4% (9•4-15•7) in symptomatic women, and 17•4% (12•5-22•8) in symptomatic men. Pooled prevalence of current rectal infection was 7•7% (4•2-12•0) in men who have sex with men. Substantial between-study heterogeneity was found. Multivariable meta-regression explained 29•0% of variation. Population type was most strongly associated with prevalence. Additional associations were found with assay type, sample size, country, and sex, but not with sampling methodology or response rate (about 90% of studies used convenience sampling and >75% had unclear response rate). There was no evidence for temporal variation in prevalence between 1982 and 2018. Interpretation C trachomatis prevalence in the Middle East and north Africa is similar to other regions, but higher than expected given its sexually conservative norms. High prevalence in infertility clinic attendees and in women with miscarriage suggests a potential role for C trachomatis in poor reproductive health outcomes in this region.

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“…It remains possible therefore that M. genitalium is a rare infection in infertile couples in this part of Iran. However, a recent study in Tehran found a prevalence of 12% and 2% in symptomatic and asymptomatic men, respectively, using PCR of first‐void urine (Yeganeh, Jeddi‐Tehrani, & Yaghmaie, ). Clearly, this is an area that requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Relationship betweenChlamydia trachomatisandMycoplasma genitaliuminfection and pregnancy rate and outcome in Iranian infertile couples

et al. 2016

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Summary The study was performed to investigate the prevalence of Chlamydia trachomatis and Mycoplasma genitalium in a population of infertile couples from Iran and how this relates to tubal factor infertility, pregnancy rate and outcome of pregnancy. Blood, semen and first‐void urine samples were obtained from 250 infertile couples and 250 fertile women as a control. Infertile couples were followed up after 24 months to determine diagnosis, referral for assisted conception, any pregnancy and pregnancy outcome. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to C. trachomatis in serum; (ii) the presence of C. trachomatis and M. genitaliumDNA in first‐void urine; and (iii) in a semen sample of the male partner. Prevalence of C. trachomatis in our study population was comparable to other studies using similar methods and test specimens. No evidence of M. genitalium infection was found. Detection of C. trachomatis in one partner rarely correlated with infection in the other. The risk of tubal factor infertility and the probability of pregnancy and pregnancy outcome were unrelated to the results of serological tests for C. trachomatis antibodies or the presence of C. trachomatisDNA in first‐void urine of both partners and in a semen sample provided by the male.

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A Survey on the Prevalence of Chlamydia Trachomatis and Mycoplasma Genitalium Infections in Symptomatic and Asymptomatic Men Referring to Urology Clinic of Labbafinejad Hospital, Tehran, Iran

Cited by 16 publications

References 23 publications

A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction

A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Relationship betweenChlamydia trachomatisandMycoplasma genitaliuminfection and pregnancy rate and outcome in Iranian infertile couples

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