A Survey on Main Semen Parameters in Natural Pregnancy and Intrauterine Insemination: Are There Any Significant Differences?

Aboutorabi, Roshanak; Zamani, Soudabeh; Zarrin, Yasaman; Mostafavi, Firoozeh

doi:10.1177/1557988316647966

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Additional factors that independently predicted pregnancy post‐CoQ10 therapy were sperm concentration and ROS. Our results are in agreement with previous studies which showed an association between sperm concentration, motility, normal morphology and pregnancy outcome (Aboutorabi et al, 2018 ; Jedrzejczak et al, 2008 ). Semen analysis and semen parameters, however, have limitations as WHO reference values of semen analysis were obtained from fertile couples, unequal distribution of population and inability to assess sperm function and fertilization (Agarwal et al, 2018 ).…”

Section: Discussionsupporting

confidence: 94%

Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy

Alahmar

Naemi

2022

Andrologia

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Different antioxidants including coenzyme Q10 (CoQ10) have been tried to treat idiopathic male infertility (IMI) with variable results. Therefore, this study aimed to determine the clinical and biochemical predictors of pregnancy outcome and time to pregnancy (TTP) in infertile men with idiopathic oligoasthenospermia (OA) pre-and post-CoQ10 therapy. This prospective controlled clinical study included 178 male patients with idiopathic OA and 84 fertile men (controls). Patients received 200 mg of oral CoQ10 once daily for 6 months. Demographics, semen parameters, seminal CoQ10 levels, reactive oxygen species (ROS) levels, total antioxidant capacity (TAC), catalase (CAT), glutathione peroxidase (GPx), sperm DNA fragmentation (SDF) and body mass index were measured and compared at baseline and after 6 months. All participants were followed up for another 18 months for pregnancy outcome and TTP. CoQ10 therapy for 6 months significantly improved semen parameters, antioxidant measures and reduced SDF. The pregnancy rate was 24.2% and TTP was 20.52 ± 6.72 months in patients as compared to 95.2% and 5.73 ± 6.65 months in fertile controls. After CoQ10 therapy, CoQ10 level, sperm concentration, motility and ROS were independent predictors of pregnancy outcome and CoQ10 level, male age, sperm concentration, motility, ROS and GPx were independent predictors of TTP in patients. In conclusion, CoQ10 therapy of 6 months is a potential treatment for men with idiopathic OA. CoQ10 level, male age, semen parameters, ROS and GPx could potentially be used as diagnostic biomarkers for male fertility and predictors for pregnancy outcome and TTP in these patients.

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Section: Discussionsupporting

confidence: 94%

Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy

Alahmar

Naemi

2022

Andrologia

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“…Since 2010, seven published studies have been identified as potentially suitable for detailed assessment. Data was kindly supplied from five published studies 4–8 (Table 1). Five studies documented using WHO standards for assessment (WHO 2010) however the morphology assessment by Aboutorabi et al 5 was not compliant with WHO 2010 and therefore has been excluded.…”

Section: Resultsmentioning

confidence: 99%

“…Data was kindly supplied from five published studies 4–8 (Table 1). Five studies documented using WHO standards for assessment (WHO 2010) however the morphology assessment by Aboutorabi et al 5 was not compliant with WHO 2010 and therefore has been excluded. Vitality assessments were only available from the study by Evgeni et al 8 Lotti et al 4 , Tang et al 7 and Zedan et al 6 After accounting for an abstinence period of 2–7 days and a TTP of ≤12 months, up to 1789 subjects were analysed (Analysis 1: 2010–2020).…”

Section: Resultsmentioning

confidence: 99%

Distribution of semen examination results 2020 – A follow up of data collated for the WHO semen analysis manual 2010

et al. 2021

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Background It is now 11 years since publication of the WHO 2010 guidelines for semen assessment values, and it is critical to determine whether they are still valid and/or whether they should be modified. Objectives To utilise data published since 2010 and combine these with data used in the 2010 assessment to provide an updated and more comprehensive representation of the fertile man. This may be utilised to present an updated distribution of values for use by WHO in 2021. Materials and Methods Two specific analyses were performed namely, (1) Analysis 1: Examination of published data following publication of WHO 2010 [termed 2010–2020 data]. (2) Analysis 2: Examination of the data used to help formulate the 2010 distribution of values combined with the data from Analysis (1) [termed WHO 2020]. Results In total, data from more than 3500 subjects, from twelve countries and five continents were analysed. The 5th centile values for concentration, motility and morphology are: 16 × 106/ml, 30% progressive motility [42% total motility] and 4% normal forms. Discussion This study presents substantial additional information to establish more comprehensive and globally applicable lower reference values for semen parameters for fertile men although they do not represent distinct limits between fertile and subfertile men. There are still data missing from many countries and, some geographical regions are not represented. Moreover, the number of subjects although significant is still relatively low (<4000). Conclusion These distributions of values now include semen analysis providing a more global representation of the fertile man. Increasing the number of subjects provides robust information that is also more geographically representative.

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“…The new dataset is freely available and was created after screening the literature with the following inclusion criteria: men with TTP ≤12 months; sexual abstinence range between 2 and 7 days; evidence of compliance with WHO 2010 laboratory techniques; assessment of internal and external quality control ( Campbell et al ., 2021 ). A total of 10 studies were included ( Bonde et al , 1998 ; Auger et al , 2001 ; Swan et al , 2003 ; Haugen et al , 2006 ; Stewart et al , 2009 ; Evgeni et al , 2015 ; Tang et al , 2015 ; Aboutorabi et al , 2018 ; Zedan et al , 2018 ; Lotti et al , 2020 ). Although this tool represents an important and widespread reference for the assessment of male fertility, its approach has been the object of some criticisms ( Esteves et al ., 2012 ; Patel et al , 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The statistical foundation of the reference population for semen analysis included in the sixth edition of the WHO manual: a critical reappraisal of the evidence

et al. 2022

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In the most recent version of the ‘WHO Laboratory Manual For The Examination And Processing Of Human Semen’, the updated target population used to infer reference values included 3589 fertile subjects, representative of 12 countries and 5 continents, and 10 studies. We have critically evaluated the newly proposed distribution of semen examination results using an approach borrowed from clinical chemistry laboratories and based on the recommendations of the International Federation of Clinical Chemistry for estimation of reference intervals. Surprisingly, most prerequisites to produce common reference intervals through multicentric data were not met. Moreover, when we assessed with the bootstrap method the descriptive reference values obtained from raw data of the 10 individual studies for sperm concentration, sperm number, motility and normal forms, we found that none of the populations was completely correctly described by the reference centiles. We concluded that aggregated data used to build the reference distribution cannot be considered to originate from the same population, and this can result from real differences among individuals or different methodological approaches used in the various studies. Transferability conditions across studies did not seem to have been met. Our findings strengthen the relevance of concerns regarding the use of reference populations in the World Health Organization manual to discriminate between fertile and infertile men.

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A Survey on Main Semen Parameters in Natural Pregnancy and Intrauterine Insemination: Are There Any Significant Differences?

Cited by 7 publications

References 27 publications

Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy

Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy

Distribution of semen examination results 2020 – A follow up of data collated for the WHO semen analysis manual 2010

The statistical foundation of the reference population for semen analysis included in the sixth edition of the WHO manual: a critical reappraisal of the evidence

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