The research paper aims to estimate the risk of automation of occupations defined by the ISCO-08 standard, at European level. The idea came from the work of the pioneers of this subject, Carl Benedikt Frey and Michael A. Osborne. Basically, we will highlight the importance of skills and knowledge in determining the risk of job automation at European level. For this we used logistic regression, which helped us to classify occupations according to the risk of automation. The results indicate that occupations that require knowledge in the fields of agriculture, forestry, fisheries, veterinary, natural sciences, mathematics, statistics, social sciences, journalism and information, but also those that require skills such as communication, collaboration, creativity and management skills, have a lower risk of automation. The risk of automation is increased instead for occupations that require skills in the categories of information skills and handling and moving skills. More specifically, occupations that involve a monotonous, repetitive activity and that require mediocre skills and knowledge, will be replaced by technology. The solutions offered by technology will be much more efficient than a human resource. Obviously, this automation will not happen for all countries at the same time and will not have the same consequences.