A survey of the pathology of marmosets (Callithrix jacchus) under experiment

Abstract

A survey of the pathology of 567 laboratory-bred cotton-eared marmosets (Callithrix jacchus) is presented. There were few significant pathological changes in animals used in studies up to 6 months in duration, suggesting that the marmoset can be a useful non-human primate species for routine toxicology. The most common pathological changes encountered were chronic colitis, chronic thyroiditis and interstitial mononuclear infiltration in the kidney. No internal parasites were encountered, nor were any viral or bacterial diseases identified. Fungal disease was confined to a few cases of oesophageal mycoses. In a long term study a variety of pathological changes have been observed, including a 'wasting' syndrome, not related to skeletal muscle myopathy, with atrophy of the gastrointestinal tract, salivary glands and gonads, haemosiderosis and fatty change in the liver and osteoporosis. It is suggested that these changes may be related to protein deficiency and that the nutritional requirements of the marmoset require further investigation.

Spontaneous and Drug-Induced Hepatic Pathology of the Laboratory Beagle Dog, the Cynomolgus Macaque and the Marmoset

“…In the so-called "weak" individuals, additional findings included cystic degeneration and inflammatory cell infiltration were seen, while in the "dead" animals, congestion and fatty change were apparent in addition to the findings described for the "healthy" individuals ( Figure 5). Extramedullary haematopoiesis (EMH) has been described as the most common change observed in a second survey by Tucker (1984) where the pathology of 567 laboratory-bred cotton-eared marmosets was reviewed. EMH was reported to be extremely sensitive to frequent bleeds, of the kind that can occur in toxicity studies.…”

Gross morphometry of the heart of the Common marmoset

“…However, diseases like myocardial fibrosis, chronic myocarditis and ventricle dilatation have been reported previously for captive individuals of C. jacchus [4,7,16,24]. To understand these and other heart pathologies, i.e., related to toxicological studies [5], it is critical to establish normal characteristics and morphological data.…”

Síndrome de emagrecimento progressivo dos calitriquídeos - processo de má absorção semelhante à doença celíaca humana - caracterização clínica, laboratorial e anatomopatológica

“…unanimemente descrevem e associam a SEP à lesão localizada essencialmente no cólon e representada por colite crônica, na qual são descritos microabscessos de criptas, infiltrado de mononucleares e polimorfonucleares na lâmina própria, diminuição das células caliciformes e atipia celular (BASKIN et al, 1983;CHALIAFOUX et al, 1993;CHALMERS et al, 1983;GOZALO & MONTOYA, 1991;JUAN-SALLÉS, 2003;KIRKWOOD et al, 1983;LUSHBAUGH et al, 1985;POTKAY, 1992;SAINSBURY et al, 1987;SCULLION et al, 1987;TUCKER, 1984).…”