A survey of the embryotoxic effects of TCDD in mammalian species.

Abstract

Images FIGURE 1.

Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the hamster, rat and guinea pig

“…Although mature animals display a wide interspecies variability to the acute toxic effects of TCDD, demonstrated by the 5000-fold difference in the acute LD 50 among species, evidence suggests that the developing embryo and fetus are uniquely sensitive to TCDD (McNulty, 1984;Olson et al, 1990;Peterson et al, 1993). There has been frequent use of the rat Gray et al, 1997;Huuskonen et al, 1994;Ikeda et al, 2005;Mably et al, 1992a,b,c) and mouse (Birnbaum et al, 1991;Ko et al, 2002;Neubert et al, 1973;Thackaberry et al, 2005;Weber and Birnbaum, 1985;Willey et al, 1998) as model systems to study the developmental toxicity of TCDD. However, only a few studies have utilized the hamster Olson and McGarrigle, 1992;Olson et al, 1990;Wolf et al, 1999) or guinea pig (Olson and McGarrigle, 1992).…”

Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a model aquatic environment

“…It is also a potent teratogen in many species of laboratory animals, causing cleft palate and kidney abnormalities (e.g. Neubert et al 1973).…”

Polybrominated dibenzo-p-dioxins and dibenzofurans: literature review and health assessment.

“…TCDD is a potent developmental toxin in mice, causing cleft palate and hydronephrosis at dose levels that produce no overt maternal or fetal toxicity (35). Birnbaumet al (34) studied the effect of substituting bromine for chlorine in the TCDD molecule on teratogenic potency.…”