A Survey of the Chromatographic Analysis of Natural Insect Juvenile Hormones and the Insect Growth Regulator, Altosid(R)

Dunham, L. L.; Schooley, David A.; Siddall, J. B.

doi:10.1093/chromsci/13.7.334

Cited by 6 publications

(7 citation statements)

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“…A considerable amount of research has been devoted both to the improvement of established classical methods (12) and more recently to the development of a fundamentally different approach. The newer approach is based on a combination of in vitro organ culture with high resolution liquid chromatography (14), and such an approach led in this laboratory to the discovery of the third natural JH (15 which has now been investigated in chemical detail.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

“…The newer approach is based on a combination of in vitro organ culture with high resolution liquid chromatography (14), and such an approach led in this laboratory to the discovery of the third natural JH (15 which has now been investigated in chemical detail. From the relatively primitive cockroaches and grasshoppers (12) to the more recently evolved moths, whose metamorphosis is considerably more complicated, the same three hormones appear to be the regulatory molecules.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

“…These methods have been published in detail (32) and reviewed recently (12). Compounding the problem of low to nondetectable residues is the absence from methoprene of elements which would allow the use of selective element-sensitive detectors; further, its chromatographic properties are extremely similar to those of several natural products.…”

Section: Residuesmentioning

confidence: 99%

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Insect Growth Regulators and Insect Control: A Critical Appraisal

Siddall¹

1976

Environmental Health Perspectives

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Section: Environmental Health Perspectivesmentioning

confidence: 99%

Section: Environmental Health Perspectivesmentioning

confidence: 99%

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Insect Growth Regulators and Insect Control: A Critical Appraisal

Siddall¹

1976

Environmental Health Perspectives

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“…Despite this apparent bonanza, even the isolation of nanogram quantities of natural JH from insects is a truly difficult task (13). A considerable amount of research has been devoted both to the improvement of established classical methods (12) and more recently to the development of a fundamentally different approach. The newer approach is based on a combination of in vitro organ culture with high resolution liquid chromatography (14), and such an approach led in this laboratory to the discovery of the third natural JH (15).…”

Section: Occurrence and Distribution Of Juvenile Hormonesmentioning

confidence: 99%

“…)< OMe which has now been investigated in chemical detail. From the relatively primitive cockroaches and grasshoppers (12) to the more recently evolved moths, whose metamorphosis is considerably more complicated, the same three hormones appear to be the regulatory molecules.…”

Section: Occurrence and Distribution Of Juvenile Hormonesmentioning

confidence: 99%

Insect growth regulators and insect control: a critical appraisal.

Siddall¹

1976

Environ Health Perspect

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Insect growth regulators (IGRs) of the juvenile hormone type alter physiological processes essential to insect development and appear to act specifically on insects. Three natural juvenile hormones have been found in insects but not in other organisms. Future use of antagonists or inhibitors of hormone synthesis may be technically possible as an advantageous extension of pest control by IGRs. A documented survey of the properties, metabolism, toxicology, and uses of the most commercially advanced chemical, methoprene, shows it to be environmentally acceptable and toxicologically innocuous. Derivation of its current use patterns is discussed and limitations on these are noted. Residue levels and their measurement in the ppb region have allowed exemption from the requirement of tolerances in the EPA registered use of methoprene for mosquito control. Tolerances for foods accompany its fully approved use for control of manure breeding flies through a cattle feed supplement. The human health effects of using this chemical appear to be purely beneficial, but further advances through new IGR chemicals appear unlikely without major changes in regulatory and legislative policy.

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