A survey of the burden of allergic rhinitis in Europe

Canonica, Giorgio Walter; Bousquet, Jean; Mullol, Joaquim; Gk, Scadding; Jc, Virchow

doi:10.1111/j.1398-9995.2007.01549.x

Cited by 385 publications

(335 citation statements)

References 29 publications

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“…Like asthma (57), allergic rhinitis is known to affect social, school and professional life as well as sleep (58)(59)(60). However, there is no existing study on NAR.…”

Section: Social Consequencesmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

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167

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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“…Like asthma (57), allergic rhinitis is known to affect social, school and professional life as well as sleep (58)(59)(60). However, there is no existing study on NAR.…”

Section: Social Consequencesmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

Self Cite

167

148

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“…Despite these clinical study results, conflicting data exist regarding the prescription rates for medications for the treatment of AR. The prescription rates for AH, a combination of AH and INS, and INS alone were 42.8%, 31.4%, and 14.8%, respectively, in a pan-European study13 and 31.5%, 42.3%, and 21.5%, respectively, in an American study12. Interestingly, the prescription rate for a combination of AH and INS was much higher (66%) in a survey in Spain37.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, several clinical trials have shown that no clinical advantages exist for combination therapy of SAR, compared with INS monotherapy7–11. Although INSs could be considered as the most efficient drugs among several classes of medications for the treatment of AR, the proportion of prescriptions for AHs and combination therapy of AH and INS were both higher than that for INS monotherapy according to surveys conducted in the US12 and in Europe13.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Hashiguchi

Kanzaki

Wakabayashi

et al. 2013

Journal of Drug Assessment

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ObjectiveThis study investigated the clinical efficacy of a combination therapy of levocetirizine (LCTZ) and fluticasone furoate nasal spray (FFNS), compared with LCTZ monotherapy, for the suppression of seasonal allergic rhinitis (SAR) symptoms induced in an artificial exposure chamber.MethodsThis study was a single-center, placebo-controlled, randomized, 3-way cross-over comparative study performed in 42 Japanese cedar pollinosis patients. These subjects received (1) LCTZ plus FFNS (combination group), (2) LCTZ plus FFNS placebo (monotherapy group), or (3) LCTZ placebo plus FFNS placebo (placebo group) once on the night prior to exposure, with a 1-week washout period between exposures. Nasal (sneezing, rhinorrhea, nasal congestion, and itchy nose) and ocular (eye itching and tearing) symptoms were recorded every 15 min, and the number of sneezes, nose blowing events, and the amount of nasal secretions were measured during exposure. The primary end-point was the cumulative incidence of SAR symptoms during exposure and the ‘ime to occurrence of symptoms’. The secondary end-points were the total nasal symptom score, the ocular symptom score, the amount of nasal discharge, and the number of sneezes and nose blowing events.ResultsAt all the measurement points, the lowest cumulative incidences for the nasal symptoms were observed in the combination group, followed by the monotherapy and placebo groups. All the subjects in the placebo group developed nasal symptoms within 2 h after pollen exposure, while three and eight subjects in the monotherapy and combination groups, respectively, did not develop any nasal symptoms during exposure. In addition, combination therapy delayed the onset of symptoms.ConclusionsThe results demonstrated that combination therapy with FFNS and LCTZ significantly suppressed the induced SAR symptoms and delayed the onset of symptoms compared with LCTZ monotherapy and placebo. Although the conditions of the allergen challenge study using an exposure chamber are different from those in real life, combination therapy with FF and LCTZ was confirmed to be an effective treatment for SAR.

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“…Allergic rhinoconjucntivitis is the associated watery eyes, itching, burning/irritability, redness and injection of the conjunctiva which has been documented in 71% of European patients who concurrently had nasal symptoms [6].…”

Section: Allergic Rhinitismentioning

confidence: 99%

Response to Combination Intranasal Corticosteroid and Intranasal Antihistamine in Allergic Rhinitis, A Questionnaire Based Study in ENT Outpatients

Sami¹,

Ahmed²,

Ahmed³

2017

Otolaryngol (Sunnyvale)

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A survey of the burden of allergic rhinitis in Europe

Cited by 385 publications

References 29 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Response to Combination Intranasal Corticosteroid and Intranasal Antihistamine in Allergic Rhinitis, A Questionnaire Based Study in ENT Outpatients

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A survey of the burden of allergic rhinitis in Europe

Cited by 385 publications

References 29 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Response to Combination Intranasal Corticosteroid and Intranasal Antihistamine in Allergic Rhinitis, A Questionnaire Based Study in ENT Outpatients

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper