A Survey of Synthetic Routes Towards the Pyranonaphthoquinone Antibiotic Pentalongin and Syntheses of the Corresponding Nitrogen Derivatives

Claessens, Sven; Verniest, Guido; Jacobs, Jan; Hende, Eva Van; Habonimana, Pascal; Van, Tuyen Nguyen; Puyvelde, Luc Van; Kimpe, Norbert De

doi:10.1002/chin.200727227

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2018

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“…and have been utilized by mankind during many years (1,2). These structures could be either isolated from natural products or synthesized in the laboratories by applying various experimental methods (3)(4)(5)(6)(7)(8). Plenty of molecules which belong to quinone family are particularly biologically active compounds and possess antitumor, cytotoxic, anticancer, antimalarial, and antifungal properties (9)(10)(11)(12)(13).…”

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confidence: 99%

Synthesis and Characterization of New Cyclic Aminobenzoquinones

Tuyun

Yıldız

2018

Journal of the Turkish Chemical Society Section A: Chemistry

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The aim of this research is to synthesize and characterize new members of cyclic aminobenzoquinones. Mono amino substituted products, namely 2-chloro-5,6-dimethyl-3-(pyrrolidin-1-yl)-1,4-benzoquinone (2), 2-chloro-5,6-dimethyl-3-(piperidin-1-yl)-1,4benzoquinone (3), 2-chloro-5,6-dimethyl-3-morpholino-1,4-benzoquinone (4), and 2-chloro-5,6dimethyl-3-thiomorpholino-1,4-benzoquinone (5) have been synthesized by the nucleophilic substitution reactions between 2,3-dichloro-5,6-dimethyl-1,4-benzoquinone (1) and cyclic secondary amines with a green methodology using water as solvent. Structure determination of the new products (2-5) was established on the basis of FTIR, 1 H NMR, 13 C NMR, and mass spectrometry.

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