A Survey of Strain‐Promoted Azide–Alkyne Cycloaddition in Polymer Chemistry

Abstract

Highly efficient reactions that enable the assembly of molecules into complex structures have driven extensive progress in synthetic chemistry. In particular, reactions that occur under mild conditions and in benign solvents, while producing no by‐products and rapidly reach completion are attracting significant attention. Amongst these, the strain‐promoted azide–alkyne cycloaddition, involving various cyclooctyne derivatives reacting with azide‐bearing molecules, has gained extensive popularity in organic synthesis and bioorthogonal chemistry. This reaction has also recently gained momentum in polymer chemistry, where it has been used to decorate, link, crosslink, and even prepare polymer chains. This survey highlights key achievements in the use of this reaction to produce a variety of polymeric constructs for disparate applications.

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

“…In recent years, 1 H -1,2,3-Triazoles are of increasing interest to researchers as one of the most promising classes of heterocyclic compounds for different purposes of bioconjugation [ 1 ] design of new catalysts [ 2 ], supramolecular ensembles [ 3 , 4 ], and polymeric materials [ 5 ]. 1,2,3-Triazoles are widely synthetically available compounds due to the development of simple and effective methods of their preparation on the base of “click” reaction of Cu-catalyzed azide–alkyne cycloaddition (CuAAC) [ 6 , 7 , 8 , 9 , 10 ].…”

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

“…The study on the in vitro drug release showed enhanced drug release at an acidic pH value in comparison to a neutral pH value. Importantly, the amount of DOX required for MCF-7 cells was decreased after the support of DOX molecules on the polymer prodrug, which resulted in reduced side effects ( Scheme 18b ) [ 48 – 49 ].…”

Iodine-based reagents in photoredox-organocatalysis

“…Alkynes are synthetically important moieties that can further be transformed into many functionalized molecules. [63][64] Therefore, the development of improved methods for the synthesis of alkynes is essential in organic chemistry. 65 For the first time, in 2016, Cheng and coworkers reported a method for decarboxylative alkynylation of carboxylic acids 12 using organo-photocatalyst (Figure 6).…”