A Survey of Some Wood-Destroying and Other Fungi for Antibacterial Activity

Rôbbins, William J.; Hervey, Annette; Davidson, Ross W.; Ma, Roberta; Robbins, William C.

doi:10.2307/2481273

Cited by 36 publications

(14 citation statements)

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“…Robbins et al (1945) found no antibiotic production in this species and we have often isolated antibiotically inactive M . rarnannianus.…”

Section: Cultural Characteristics Of the Fungusmentioning

confidence: 72%

Ramycin: A New Antibiotic

Dijck¹,

Somer²

1958

Journal of General Microbiology

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SUMMARY: A strain of nlucor ramannianus from Campine forest soil was found to secrete an antibiotic, for which the name Ramycin is proposed. It is especially active against Gram-positive micro-organisms and Myobacterium tuberculosis H37Rv, but sensitive organisms quickly acquire resistance to it. Although it is not very toxic, it possesses a necrotic action on tissues. Ramycin can protect mice against streptococcal and staphylococcal infections but not against H 37 Rv.Ramycin crystallizes in orthorhombic plates. The new antibiotic is an opticallyinactive unsaturated hydroxy acid, containing C, H and 0 only.

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“…Robbins et al (1945) found no antibiotic production in this species and we have often isolated antibiotically inactive M . rarnannianus.…”

Section: Cultural Characteristics Of the Fungusmentioning

confidence: 72%

Ramycin: A New Antibiotic

Dijck¹,

Somer²

1958

Journal of General Microbiology

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“…1) (2aa,4ab,5b,6b,8aa,12bb,12cb,12db)-(À)-2a,3,4,4a,5,6,7,8a,12b,12c-Decahydro-6-methyl-2H-5,12d-ethanofuro[4¢,3¢,2¢:4,10] anthra[9,1-bc]oxepin-2,9, 12-trione, CAS 1404-23-5, NSC 401005, C 21 H 22 O 5 , MW 354.40, a naphthoquinone antibiotic, was discovered by Robbins in 1947 as the substance produced by Pleurotus griseus which is toxic to gram positive bacteria [6,7]. The same compound, but named geogenine, was subsequently reisolated from Geopetalum geogerium, and subsequently found from Hohenbuehelia spp.…”

Section: Introductionmentioning

confidence: 99%

Development of a process for the production of the anticancer lead compound pleurotin by fermentation of Hohenbuehelia atrocaerulea

Shipley¹,

Barr²,

Graf³

et al. 2006

J IND MICROBIOL BIOTECHNOL

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Pleurotin is a naphthoquinone antibiotic originally isolated from Pleurotus griseus. Two pleurotin producing strains of Hohenbuehelia atrocaerulea have been identified, which, on solid substrate fermentation for 2 months yield 1-2 mg/l of the antibiotic. Described here is the lengthy developmental process which resulted in a production protocol being developed which reliably yields pleurotin from liquid fermentation at >300 mg/l. Critical to obtaining this increase in titer was inclusion in the media of an aqueous extract of alder wood.

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“…Antibacterial activity was observed in a fungal or plant extract, and when the active principle was isolated and characterized, it proved to be a polyacetylene. Of the following examples, the first five were detected as the result of the earliest surveys of Basidiomycetes for antibiotic activity, (WILKINS and HARRIS, 1944;ROBBINS et al, 1945;HERVEY, 1947), the last four as the result of isolated investigations of antibiotic principles from three different types of organisms.…”

mentioning

confidence: 99%

Biogenesis and Biological Activity of Polyacetylenes

Anchel¹

1967

Biosynthesis

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A Survey of Some Wood-Destroying and Other Fungi for Antibacterial Activity

Cited by 36 publications

References 0 publications

Ramycin: A New Antibiotic

Ramycin: A New Antibiotic

Development of a process for the production of the anticancer lead compound pleurotin by fermentation of Hohenbuehelia atrocaerulea

Biogenesis and Biological Activity of Polyacetylenes

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