A survey of smartphone and interactive video technology use by participants in Alzheimer's disease research: Implications for remote cognitive assessment

Jacobs, Diane M.; Peavy, Guerry M.; Banks, Sarah J.; Gigliotti, Christina; Little, Emily E.; Salmon, David P.

doi:10.1002/dad2.12188

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Smartphones, which are becoming ubiquitous, 12,13 may provide a vehicle for addressing recruitment challenges in FTD research and potentially improving sensitivity to early symptoms. We previously found that digital tests of executive functioning, which is affected across FTD syndromes, detected deficits in asymptomatic f‐FTD mutation carriers 14 .…”

Section: Introductionmentioning

confidence: 99%

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Taylor

Heuer

Clark

et al. 2023

Alz & Dem Diag Ass & Dis Mo

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Introduction Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD‐mApp). Methods A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC‐FTLD = 0 [ N = 101]; prodromal: 0.5 [ N = 49]; symptomatic ≥1 [ N = 51]; not measured [ N = 13]) were asked to complete ALLFTD‐mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. Results It was feasible for participants to complete the ALLFTD‐mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests. Discussion These findings suggest that the ALLFTD‐mApp study protocol is feasible and acceptable for remote FTD research. HIGHLIGHTS The ALLFTD Mobile App is a smartphone‐based platform for remote, self‐administered data collection. The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities. Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders. Remote digital data collection was well accepted by participants with a variety of diagnoses.

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Section: Introductionmentioning

confidence: 99%

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Taylor

Heuer

Clark

et al. 2023

Alz & Dem Diag Ass & Dis Mo

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“…However, recent research has suggested that remote (i.e., delivered via online or via mail) assessments are both acceptable and feasible for many participants and study partners (Geddes et al, 2020). Remote assessment has not only been shown to be feasible in young, cognitively unimpaired individuals, but also in older individuals with and without neurological and/or psychiatric disorders (D'Arcy et al, 2013;George et al, 2016;Wadsworth et al, 2016;Jacobs et al, 2021;Lavigne et al, 2021). For impaired participants, remote assessment might be preferred to reduce participant and study-partner burden as traveling into clinic becomes more physically challenging.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer’s Disease Biomarkers and Mood Symptoms

Munro

Buckley

Vannini

et al. 2022

Front. Aging Neurosci.

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Whereas discrepancies between participant- and study partner-reported cognitive concerns on the Alzheimer’s disease (AD) continuum have been observed, more needs to be known regarding the longitudinal trajectories of participant- vs. study partner-reported concerns, particularly their relationship to AD biomarkers and mood symptomology. Additionally, it is unclear whether years of in-clinic data collection are needed to observe relationships with AD biomarkers, or whether more frequent, remote assessments over shorter periods of time would suffice. This study primarily sought to examine the relationships between longitudinal trajectories of participant- and study partner-rated cognitive decline and baseline biomarker levels [i.e., amyloid and tau positron emission tomography (PET)], in addition to how mood symptomatology may alter these trajectories of concerns over a 2-year period. Baseline mood was associated with longitudinal participant-rated concerns, such that participants with elevated depression and anxiety scores at baseline had decreasing concerns about cognitive decline over time (fixed estimate = −0.17, 95% CI [−0.29 to −0.05], t = −2.75, df = 457, adj. p = 0.012). A significant interaction between baseline amyloid (fixed estimate = 4.07, 95% CI [1.13–7.01], t = 2.72, df = 353, adj. p = 0.026) and tau (fixed estimate = 3.50, 95% CI [0.95–6.06], t = 2.70, df = 331, adj. p = 0.030) levels was associated with increasing study partner concerns, but not participant concerns, over time. The interaction between amyloid and study partner concerns remained significant when utilizing only the first year of concern-related data collection. Overall, these results suggest that frequent, remote assessment of study partner-reported concerns may offer additional insight into the AD clinical spectrum, as study partners appear to more accurately update their concerns over time with regard to pathology, with these concerns less influenced by participants’ mood symptomatology.

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“…Although previously reported adherence rates to online assessments vary, the rate we observed is consistent with the previous literature examining remote monitoring for more than three months. 23 , 25 , 53 , 66 Direct comparisons between adherence rates are difficult, however, due to heterogeneity in the duration of monitoring (8 days – 1 year), 25 , 53 the frequency of assessment (3 times a day – once a month), 25 , 67 and the patient population included (healthy controls or patient groups). 23 , 53 From this heterogeneity, it appears that shorter study periods demonstrate higher rates of adherence, yet our work suggests that the adherence rate over a three-month period is high enough to provide valuable insights into an individual's functional status.…”

Section: Discussionmentioning

confidence: 99%

The feasibility of remotely monitoring physical, cognitive, and psychosocial function in individuals with stroke or chronic obstructive pulmonary disease

French

Keatley

et al. 2023

DIGITAL HEALTH

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Objective Clinical implementation of remote monitoring of human function requires an understanding of its feasibility. We evaluated adherence and the resources required to monitor physical, cognitive, and psychosocial function in individuals with either chronic obstructive pulmonary disease or stroke during a three-month period. Methods Seventy-three individuals agreed to wear a Fitbit to monitor physical function and to complete monthly online assessments of cognitive and psychosocial function. During a three-month period, we measured adherence to monitoring (1) physical function using average daily wear time, and (2) cognition and psychosocial function using the percentage of assessments completed. We measured the resources needed to promote adherence as (1) the number of participants requiring at least one reminder to synchronize their Fitbit, and (2) the number of reminders needed for each completed cognitive and psychosocial assessment. Results After accounting for withdrawals, the average daily wear time was 77.5 ± 19.9% of the day and did not differ significantly between months 1, 2, and 3 ( p = 0.30). To achieve this level of adherence, 64.9% of participants required at least one reminder to synchronize their device. Participants completed 61.0% of the cognitive and psychosocial assessments; the portion of assessments completed each month didnot significantly differ ( p = 0.44). Participants required 1.13 ± 0.57 reminders for each completed assessment. Results did not differ by disease diagnosis. Conclusions Remote monitoring of human function in individuals with either chronic obstructive pulmonary disease or stroke is feasible as demonstrated by high adherence. However, the number of reminders required indicates that careful consideration must be given to the resources available to obtain high adherence.

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A survey of smartphone and interactive video technology use by participants in Alzheimer's disease research: Implications for remote cognitive assessment

Abstract: Introduction:Participants from a longitudinal cohort study were surveyed to evaluate the practical feasibility of remote cognitive assessment.

Cited by 10 publications

References 10 publications

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer’s Disease Biomarkers and Mood Symptoms

The feasibility of remotely monitoring physical, cognitive, and psychosocial function in individuals with stroke or chronic obstructive pulmonary disease

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