A Survey of Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy in Japan

Ogo, Etsuyo; Komaki, Ritsuko; Fujimoto, Kiminori; Uchida, Masafumi; Abe, Toshi; Nakamura, Katsumasa; Mitsumori, Michihide; Sekiguchi, Kenji; Kaneyasu, Yuko; Hayabuchi, Naofumi

doi:10.1016/j.ijrobp.2007.09.003

Cited by 41 publications

(56 citation statements)

References 21 publications

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“…Ten Japanese epidemiological studies were identified [15][16][17][18][19][20][21][22][23][24]. Several studies were from a single institution [16,17,20,21,23,24], and one study was a survey among 20 institutions (Table 1) [18].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies were from a single institution [16,17,20,21,23,24], and one study was a survey among 20 institutions (Table 1) [18]. These reports described BOOP occurring in 129 of 7,671 women (1.7%), and studies showed a range of prevalence from 0.8% to 2.9% [15][16][17][18][19][20][21][22][23][24]. Five of the 9 reports showed patients received a traditional whole-breast irradiation protocol of 50 Gy in 25 fractions [19][20][21]23, 24], 1 report showed 248 patients received hypofractionated whole-breast radiotherapy [17], 1 report included patients who received whole-breast irradiation or accelerated hyperfractionated whole-breast irradiation [15], and there was no information about the radiation protocol for 3 reports.…”

Section: Resultsmentioning

confidence: 99%

“…Boost radiation was given from 0% [23] to 75% [15]. A pulmonary follow-up protocol consisting of scheduled chest radiographs during the year after treatment was used in six studies [15-17, 20, 21, 24], and chest radiographs were performed in three studies if respiratory symptoms developed [18,19,23].…”

Section: Resultsmentioning

confidence: 99%

“…Clinical and treatment data in Table 2 show that 100% of women were nonsmokers in 5 studies [15,16,18,21,23]; 1 study reported 88% nonsmokers [24], and another study reported 92% nonsmokers [20]. The majority of women received hormonal therapy, and those receiving chemotherapy ranged from 0% [22] to 60% [23].…”

Section: Resultsmentioning

confidence: 99%

“…Additional reports were published from the United States, Japan, and other countries [6,. Large-scale epidemiological reports have been published from Japan, where prevalence ranged from 0.8% to 2.9% [15][16][17][18][19][20][21][22][23][24]. Most of these patients received traditional whole-breast irradiation.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Epler

Kelly

2014

The Oncologist

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Background. Radiation therapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP).This inflammatory lung disorder was first noted in 1983, and there have been numerous reports of BOOPoccurring in womenwho have had radiation therapy for breast cancer since 1995.This study was undertaken to perform a systematic review of postradiotherapy BOOP to determine the occurrence, presentation, treatment, and outcome. Materials and Methods. A systematic literature review was conducted according to the guidelines provided by the Preferred ReportingItemsforSystematicReviewsandMeta-Analysesreport. Results. The literature search yielded 10 Japanese epidemiological reports with 129 women, 4 case series reports with 36

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Epler

Kelly

2014

The Oncologist

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Steroid treatment increases the recurrence of radiation‐induced organizing pneumonia after breast‐conserving therapy

et al. 2014

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Radiation-induced organizing pneumonia (RIOP) is an important complication of postoperative radiotherapy for breast cancer. Unfortunately, conventional corticosteroid therapy is frequently associated with relapses. The aim of this retrospective study was to evaluate the outcomes of steroid treatment in patients with RIOP. In total, 26 patients diagnosed with RIOP from among 2404 women who received radiotherapy after breast-conserving surgery for breast cancer were included and classified into steroid (n = 7) and nonsteroid (n = 19) groups. Serum, sputum, and bronchoalveolar lavage composition; subjective symptoms (cough, fever, and dyspnea); migratory progression; and RIOP relapse were compared between the groups. Treatment type did not affect the duration of the subjective symptoms, which was 1.6 and 1.7 months for the steroid and nonsteroid groups, respectively. In contrast, RIOP relapse and new pulmonary lesions developed in five patients in the steroid group and only three patients in the nonsteroid group (P = 0.014). By assessing RIOP duration as the time to resolution of symptoms and discontinuation of therapy, the median duration of RIOP was significantly longer in the steroid (17.1 months) than that in the nonsteroid group (2.3 months, P = 0.005), primarily because of frequent relapses. After remission, persistent pulmonary dysfunction did not occur in the nonsteroid group. This single-center retrospective study demonstrates that steroid therapy results in frequent relapses and significantly prolongs RIOP duration. Corticosteroid treatment is considered a critical factor in RIOP recurrence.

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Radiation Response of the Normal Lung Tissue and Lung Tumors

2011

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A Survey of Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy in Japan

Cited by 41 publications

References 21 publications

Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Steroid treatment increases the recurrence of radiation‐induced organizing pneumonia after breast‐conserving therapy

Radiation Response of the Normal Lung Tissue and Lung Tumors

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