A survey of pig sera for the presence of antibodies to the psittacosis-lymphogranuloma-venereum group of organisms

Wilson, Matt; Plummer, Patricia

doi:10.1016/0021-9975(66)90064-8

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…There also may be a tendency to incriminate known pathogens in certain diseases of swine, thus ignoring a possible synergistic role for chlamydiae. Serologic surveys done in Europe suggested that exposure to chlamydiae is widespread among swine 3,20 In limited serologic testing using a microimmunfluorescence test, > 90% of pigs tested had antibodies to chlamydiae (Anderson et al, unpublished data). Additional studies are necessary to clarify the role of chlamydiae in the pathogenesis of swine diseases.…”

Section: Discussionmentioning

confidence: 99%

Lung and Nasal Lesions Caused by a Swine Chlamydial Isolate in Gnotobiotic Pigs

1996

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Abstract. Abstract. The objective of this study was to determine whether a chlamydial isolate recovered from nasal swabs from swine with pneumonia could cause pneumonia and rhinitis in gnotobiotic pigs. The identity of the isolate currently is unknown, but it shares characteristics with Chlamydia trachomatis. After propagation in Vero cells and preparation of the inoculum (2.5 x 10 10 inclusion-forming units/ml), Chlamydiae were instilled into nostrils (1.0 ml/nostril) and lungs (2.0 ml intralaryngeally) of 15 anesthetized 3-day-old gnotobiotic piglets. Five age-matched gnotobiotic piglets were anesthetized and sham infected with uninfected cell culture lysates. Two treated piglets were moribund and 2 were severely dyspneic prior to necropsy 7 days postinfection (DPI), whereas remaining treated piglets showed mild dyspnea upon exertion throughout the study. All treated piglets developed diarrhea. All treated piglets necropsied 7-21 DPI had extensive consolidation in cranial, middle, and accessory lung lobes; a majority of these piglets also had extensive consolidation in the caudal lobes. Treated piglets necropsied 28 and 35 DPI had a lobular pattern of consolidation in all lung lobes. Histologically, lesions in lungs from treated piglets necropsied 7, 14, and 21 DPI were characterized by bronchointerstitial pneumonia with foci of type II pneumocyte hypertrophy and hyperplasia; pneumocytes and bronchial and bronchiolar epithelial cells were markedly vacuolated. Alveolar macrophages, peribronchitis, peribronchiolitis, and perivasculitis were seen in lungs from treated piglets necropsied 28 and 35 DPI; those necropsied 28 DPI also had foci of lymphohistiocytic and plasmacytic infiltrates. Turbinate lesions in all treated piglets were characterized by mild multifocal lymphoplasmacytic and occasionally neutrophilic rhinitis. Immunohistochemistry detected chlamydial antigen in bronchial and bronchiolar epithelial cells, pneumocytes, and inflammatory cells in treated piglets necropsied 7, 14, and 21 DPI. Positive staining was limited to alveolar macrophages in treated piglets necropsied 28 and 35 DPI. Chlamydial antigen was detected in turbinate epithelial cells at all necropsy intervals. Ultrastructurally, chlamydiae were seen with glycogen particles in vacuoles or free in the cytoplasm of bronchial and bronchiolar epithelial cells and pneumocytes. The results indicated that the chlamydial isolate used in this Chlamydiae have been associated with pneumonia, 17 enteritis, 11,13 conjunctivitis, 14 polyarthritis, 6 pericarditis, 19 perinatal mortality, 22 and reproductive disorders 15,21 in swine; however, the diagnostic and economic significance is unknown. Most of these reports have been based on histopathology, electron microscopy, and in some cases the isolation of chlamydiae. Many of the chlamydial isolates recovered from these disease syndromes are no longer available for study, and only a limited number of these isolates have been characterized.We recently recovered a chlamydial isolate from nasal swabs from pigs...

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Section: Discussionmentioning

confidence: 99%

Lung and Nasal Lesions Caused by a Swine Chlamydial Isolate in Gnotobiotic Pigs

1996

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“…At that time, Wilson and Plummer [50] discovered antibodies against Chlamydiaceae by capillary agglutination testing in 23% of sera derived from pigs in Great Britain.…”

Section: Epidemiology Of Infections With Chlamydiaceae In Pigsmentioning

confidence: 99%

Chlamydiaceae infections in pig

Schautteet

Vanrompay

2011

Vet Res

130

128

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Chlamydiaceae are Gram-negative obligate intracellular bacteria. They are responsible for a broad range of diseases in animals and humans. In pigs, Chlamydia suis, Chlamydia abortus, Chlamydia pecorum and Chlamydia psittaci have been isolated. Chlamydiaceae infections in pigs are associated with different pathologies such as conjunctivitis, pneumonia, pericarditis, polyarthritis, polyserositis, pseudo-membranous or necrotizing enteritis, periparturient dysgalactiae syndrome, vaginal discharge, return to oestrus, abortion, mummification, delivery of weak piglets, increased perinatal and neonatal mortality and inferior semen quality, orchitis, epididymitis and urethritis in boars. However, Chlamydiaceae are still considered as non-important pathogens because reports of porcine chlamydiosis are rare. Furthermore, Chlamydiaceae infections are often unnoticed because tests for Chlamydiaceae are not routinely performed in all veterinary diagnostic laboratories and Chlamydiaceae are often found in association with other pathogens, which are sometimes more easily to detect. However, recent studies have demonstrated that Chlamydiaceae infections in breeding sows, boars and piglets occur more often than thought and are economically important. This paper presents an overview on: the taxonomy of Chlamydiaceae occurring in pigs, diagnostic considerations, epidemiology and pathology of infections with Chlamydiaceae in pigs, public health significance and finally on prevention and treatment of Chlamydiaceae infections in pigs.

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“…The positive rate in horses was 2.2% in Japan (9), 7.1% in Finland (20) and 14.8% in Germany (27). The positive rate in pigs was 0.7%, 7.7%, 8% and 10.9% in Japan, Czechoslovakia, the United States and Scotland, respectively (9,15,28,36). The positive rate in monkeys was 9.0-14.4% in Japan (1).…”

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confidence: 99%