A Survey of Phytotoxic Microbial and Plant Metabolites as Potential Natural Products for Pest Management

Schrader, Kevin K.; Andolfi, Anna; Cantrell, Charles L.; Cimmino, Alessio; Duke, Stephen O.; Osbrink, Weste L. A.; Wedge, David E.; Evidente, Antonio

doi:10.1002/cbdv.201000041

Cited by 47 publications

(51 citation statements)

References 48 publications

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“…Metabolites 3 , 4 and 6 showed lower antifungal activity, although still significant. Metabolite 5 was less effective, with only some slight but significant inhibition on germination at 10 −2 M. Metabolite 7 reduced spore germination at all concentrations, reaching reductions similar to the fungicide when applied at 10 −2 M (Table ), confirming previous results on plant pathogenic fungi such as rusts, Colletotrichum and Phomopsis . Effects on E. pisi spore germination by metabolites 8 – 12 were moderate to low, not comparable to the fungicide at any concentration.…”

Section: Resultssupporting

confidence: 82%

Impact of fungal and plant metabolites application on early development stages of pea powdery mildew

Barilli

González-Bernal

Cimmino

et al. 2019

Pest Management Science

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BACKGROUND Pea powdery mildew incited by Erysiphe pisi represents a major constraint for pea crops worldwide. Crop protection is largely based on chemical control, although recently a renewed interest in the discovery of natural products as alternatives to synthetic fungicides application has emerged. Thus, 12 bioactive plant and fungal metabolites belonging to different class of natural compounds were evaluated, together with a commercial fungicide, at different concentrations on detached pea leaves for their potential to inhibit spore germination and subsequent stages of fungal growth. The most effective metabolites were tested at different concentrations in planta under controlled conditions to evaluate the level of control achieved by treatments before, concurrently and after pathogen inoculation. Pathogen development was macroscopically scored on whole plants as percentage of disease severity and area under the disease progress curve. RESULTS Cavoxin, inuloxin C and sphaeropsidin A strongly inhibited E. pisi germination and haustoria formation and reduced colony size. This effect was dose dependent. These results were further confirmed in whole plants by spraying the metabolites on plant leaves for preventive or curative control, which reduced fungal developmental of E. pisi at levels comparable with those obtained by application of the fungicide. CONCLUSIONS Cavoxin, inuloxin C and sphaeropsidin A have potential as alternatives to synthetic fungicides for the control of crop pathogens of economic importance such as powdery mildew. © 2019 Society of Chemical Industry

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Section: Resultssupporting

confidence: 82%

Impact of fungal and plant metabolites application on early development stages of pea powdery mildew

Barilli

González-Bernal

Cimmino

et al. 2019

Pest Management Science

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“…Without the use of chemicals, however, crops are threatened by the disease and insect damage (Perry et al, 1998;Isman, 2006). Consequently, herb extracts are increasing attracting attention as the botanical insecticides (Tripathi et al, 2009;Farooq et al, 2010;Schrader et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Repellent Effect of Herb Extracts on the Population of Wingless Green Peach Aphid, Myzus persicae Sulzer (Hemiptera: Aphididae)

Ikeura¹,

Kobayashi²,

Hayata³

2012

JAS

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Investigation of the repellent and insecticidal effects of 8 kinds of herb extracts (chives, dokudami, eucalyptus, lavender, peppermint, cherry sage, sweet pepper and tansy) against wingless green peach aphids were conducted in laboratory and field test.In laboratory repellent tests, 20 aphids were placed between a radish leaf and filter paper for 16 h and aphids on radish leaf were calculated. In laboratory insecticide tests, 20 aphids were placed on a radish leaf treated with herb extract, and live aphids were counted after 16 h. In field tests, the number of aphids that propagated on radish leaves treated with each herb extract was assessed every 3 days.In the laboratory, dokudami, tansy and sweet pepper extracts repelled aphids, while chives, sweet pepper and tansy extracts killed them. In particular, sweet pepper and tansy extracts proved to be a potent insecticide against aphids.In the field test, the results found that extracts from dokudami, cherry sage and lavender had repellent effect on aphids. In particular, dokudami extract was a highly effective repellent against aphids. These findings suggest that dokudami extract can be used to control wingless green peach aphids in the field.

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“…Lycorine and some its derivatives were assayed for algicide, bactericide, insecticide, fungicide, and herbicide activities. 1 and 1‐ O ‐acetyllycorine and lycorine hydrochloride showed high phytotoxicity in the herbicide bioassay (Table ) …”

Section: Lycorine Alkaloids Subgroupmentioning

confidence: 99%

Amaryllidaceae alkaloids: Absolute configuration and biological activity

et al. 2017

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Plants belonging to the Amaryllidaceae family are well known for their ornamental and medicinal use. Plant members of this group are distributed through both tropical and subtropical regions of the world and are dominant in Andean South America, the Mediterranean basin, and southern Africa. Amaryllidaceae plants have been demonstrated to be a good source of alkaloids with a large spectrum of biological activities, the latter being strictly related to the absolute stereochemistry of the alkaloid scaffold. Among them, great importance for practical applications in medicine has galanthamine, which has already spawned an Alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase. Furthermore, lycorine as well as its related isocarbostyryl analogs narciclasine and pancratistatine have shown a strong anticancer activity in vitro against different solid tumors with malignant prognosis. This review addresses the assignment of the absolute configuration of several Amaryllidaceae alkaloids and its relationship with their biological activities.

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A Survey of Phytotoxic Microbial and Plant Metabolites as Potential Natural Products for Pest Management

Cited by 47 publications

References 48 publications

Impact of fungal and plant metabolites application on early development stages of pea powdery mildew

Impact of fungal and plant metabolites application on early development stages of pea powdery mildew

Repellent Effect of Herb Extracts on the Population of Wingless Green Peach Aphid, Myzus persicae Sulzer (Hemiptera: Aphididae)

Amaryllidaceae alkaloids: Absolute configuration and biological activity

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