Objectives: Evidence-based practice (EBP) is an approach to making quality decisions and providing nursing care based upon personal clinical expertise in combination with the most current, relevant research available on the topic. EBP can significantly affect mortality and morbidity rates and play an important role in the reduction of geographic differences. Ten/fifteen years ago in our country, "Health Transition Project" was launched to improve the quality of health care. Thus it should be investigated to better understand nurses' current perceived barriers to research utilization. This study aim to investigate barriers of research utilization among nurses at a public hospital and radical changes of its health care system. Materials and Methods: This study was planned as a descriptive research. This study was conducted between the dates of February-May 2018 at a Public Hospital in Turkey. All participant who volunteered to participate in the survey and who completed fully form were evaluated. Simple random sampling method was used. Data were collected using a face-to-face interview technique with the questionnaire developed by the researchers and Barriers to Research Utilization Scale Turkish version. The BARRIERS scale developed by Funk consists of 29 items and four subgroups. These four factors were labeled nurse, organization, innovation and communication. As obtained the scale score increases obstacle is increasing. Results: A total of 350 nurses participated in this survey. Most of participants were undergraduate. On average, they had been employed in the nursing profession for 8.6 years (range 1-30 years). A large part of the nurses was not following the publications related to the profession (75.15%) and believed that the practical changes would provide minimal benefit (73.42%). For the organizational factors, the biggest barriers reported were "physicians will not cooperate with implementation" (76.85%). For the innovation factors the biggest barriers determined were "the nurse is uncertain whether to believe the results of the research (72.57%). For the communication factors, the biggest barriers reported were "literature is not compiled in one place" (66.85%). Conclusion: Nurses have serious barriers to using research results in clinics. These barriers range from individual characteristics of nurses to organizational factors. Therefore, focusing only on nurses is not the right approach in solving the problem. The only solution is to ensure secular, rational and scientific education for all individuals from the early childhood. Only in this way can both individual and from management organizational barriers arising can be overcome.