This study examines Indonesian chemistry teachers' perceptions of socio-scientific issues (SSIs) related to COVID-19. The explored aspects include the need to introduce SSI such as COVID-19 into chemistry learning, teachers' personal efficacy beliefs regarding SSI, and the main obstacle in SSI teaching. This research was a triangulated mixed-methods design, and the data were analyzed descriptively. The 58 in-service chemistry teachers (15 males; 43 females) from 11 regions in East Java, Indonesia were chosen using a convenience sampling technique. Data were collected using a developed five-point Likert-type questionnaire. Next, a semi-structured interview was carried out with six random participants as samples. The instruments had high reliability (Cronbach's Alpha = 0.73). This research reveals that participants perceived a need to introduce SSI to increase student interest. Most of them (63.8%) agree that students need to learn and improve their decision-making skills through SSI. However, some of them (41.4%) perceived the lack of instructional time. From the interviews, it was revealed that the unavailability of relevant material was the main obstacle in SSI teaching. Nevertheless, the teachers still wanted to develop learning materials on SSI. This study implies that further design-based research is needed by integrating individual activities into coherent instructional modules.