A Survey of Estrogenic Activity in United Kingdom Inland Waters

Harries, Jule E.; Sheahan, Dave; Jobling, Susan; Matthiessen, Peter; Neall, Paula; Routledge, Edwin J.; Rycroft, R. J. G.; Sumpter, John P.; Tylor, Tina

doi:10.1897/1551-5028(1996)015<1993:asoeai>2.3.co;2

Cited by 116 publications

(164 citation statements)

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“…Steroid estrogens have been detected in influents and effluents of sewage treatment plants in different countries (Harries et al, 1996;Aherne et al, 1989;Montagnani et al, 1996;Ternes et al, 1999a;Johnson et al, 2000,;Belfroid et al, 1999;Larsson et al, 1999;Snyder et al, 1999;Lee et al, 1998;Shore et al, 1993;Kuch et al, 2001;Nasu et al, 2000). Average concentrations of steroid estrogens (E1, E2, E3 and EE2) in influents of six Italian activated sludge WTP were 52, 12, 80 and 3 ng/L, respectively (Baronti et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…For example, less than 1 ng/L of EE2 can stimulate male rainbow trout to produce vitellogenin, an egg yolk protein, which is normally associated only with the sexually mature females (Purdom et al, 1994), and 4 ng/L of EE2 can cause male fathead minnows not to develop normal secondary sexual characteristics (Länge et al, 2001). Many sewage treatment work effluents in the United Kingdom (Harries et al, 1997;Desbrow et al, 1998;Purdom et al, 1994;Harries et al, 1996;Aherne et al, 1989;Montagnani et al, 1996), Germany (Ternes et al, 1999a) , Italy , the Netherlands (Belfroid et al, 1999;Johnson et al, 2000), Sweden (Larsson et al, 1999), the United States (Snyder et al, 1999), Canada (Ternes et al, 1999a;Lee et al, 1998), and Israel (Shore et al, 1993) have been shown to contain one or more these estrogenic compounds in the low-ng/L range.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Steroid Estrogens in Wastewater Treatment Plant of A Controceptives Producing Factory

Cui

Ren

2006

Environ Monit Assess

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Steroid estrogens such as estrone (E1), 17beta-estradiol (E2), estriol (E3), and 17alpha-ethynylestradiol (EE2) have been suspected to be the main contaminants, which can affect the endocrine system of animals. Many authors have investigated these chemicals in the domestic wastewater treatment plants (WTP). However, wastewater from industries producing steroid contraceptives has not got ample attention. From the environmental point of view, the four steroids are very significant because even very low concentrations (ng/L) can cause reproductive disturbances in human, livestock and wildlife. The main purpose of the present investigation was to develop an analytical method for the determination of the four steroid estrogens present in WTP of a pharmacy factory, mainly producing contraceptive medicine in Beijing, China. Analysis was performed by solid-phase extraction (SPE) system and liquid chromatography combined with tandem mass spectrometry (LC/MS/MS). The average recoveries from effluent samples ranged from 88% to 103% and the precision of the method ranged from 9% to 4%. Based on 0.5-L wastewater samples, the limit of quantification (LOQ) was determined at 0.7 ng/L for E1, 0.8 for E2, 0.9 ng/L for E3, and 0.5 ng/L for EE2 in influent, and 1.0 ng/L for E2 and EE2, and 2.0 ng/L for E1 and E3 in effluent. In the influent samples, average concentrations of 80, 85, 73 and 155 ng/L were determined for E1, E2, E3 and EE2, respectively, showing that they were removed in this WTP to the extent of 79, 73, 85 and 67%, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Steroid Estrogens in Wastewater Treatment Plant of A Controceptives Producing Factory

Cui

Ren

2006

Environ Monit Assess

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“…In the past few years numerous effects of these EDC have emerged, including intersex of river fish, and reproductive failure and abnormalities in marine vertebrates [2,3], birds [4,5,6], alligators [7,8], and polar bears [9]. It has, for instance, been demonstrated that several STP effluents in the UK are estrogenic to fish [10,11,12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Use of vitellogenin mRNA as a biomarker for endocrine disruption in feral and cultured fish

García-Reyero¹,

Raldúa

Quirós

et al. 2004

Analytical and Bioanalytical Chemistry

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The presence of the female-specific yolk protein precursor vitellogenin in blood and liver from male fish is widely used as an indicator of endocrine disruption. We studied the induction of vitellogenin mRNA in liver from several species of fish, both maintained in fish tanks or captured in the wild. Our procedure requires minute amounts of liver samples (down to 50 mg), and can be applied to field samples if the appropriate RNA-stabilisation agent is used. We used reverse-transcriptase PCR and quantitative real-time PCR for detection and precise quantitation of vitellogenin mRNA levels. Male mummichog (Fundulus heteroclitus) exposed to 17 beta-estradiol contained levels of vitellogenin mRNA up to 30 times higher than in untreated females and treatment with nonylphenol resulted in a weak but consistent induction of this transcript. We also studied levels of vitellogenin mRNA in a population of common carp (Cyprinus carpio) from the Anoia river, a river known for its high levels of estrogenic alkylphenols. The results were consistent with recorded data for fish from this sampling site. Finally, we also detected vitellogenin mRNA in barbs (Barbus graellsi), a species for which no vitellogenin sequence was available. The use of mRNA quantitation techniques for analysis of feral and cultured fish of different species opens the possibility of more precise detection and further control of the noxious effects of contaminants on the local fauna exposed to them.

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“…The wastewater treatment system removed >95% of NP at a concentration of 200 ppb, so that an ecologically safe concentration of less than 10 ppb of NP remained. The system performed well without the addition of nutrients or controlling the temperature of the wastewater over a range of pHs (6)(7)(8). Furthermore, the simple serial connection of columns improved the NP-degrading activity of the system during high-speed (1 l/h) treatment.…”

Section: Bacterial Biomass On the S-3 T Beadsmentioning

confidence: 99%

“…Widespread sexual disruption or ¢¢feminization¢¢ has been observed in riverine fish in several developed nations and is thought to be due to endocrine-disrupting chemicals (EDCs) in the effluent [7,8,10,14]. One of the likely suspects is nonylphenol (NP), an important intermediate in the production of many commercial and industrial materials, which is a ubiquitous pollutant in urban aquatic environments [1,3,6,8,9,11,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Potential of a new biotreatment: Sphingomonas cloacae S-3 T degrades nonylphenol in industrial wastewater

Fujii

Yamamoto²,

Tanaka³

et al. 2003

Journal of Industrial Microbiology and Biotechnology

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Sphingomonas cloacae S-3(T), a nonylphenol (NP)-degrading bacterium, was evaluated for its utility in the remediation of NP-contaminated wastewater. In flask-scale experiments, S-3(T) cells immobilized on porous polypropylene carriers (beads) efficiently degraded NP to concentrations routinely measured in aquatic environments [a few parts per billion (ppb), or micrograms per liter). Therefore, we constructed and evaluated a laboratory-scale wastewater treatment system with a 3-l carrier-filled column. The system worked properly and consistently removed several hundred ppb of NP to ecologically safe concentrations of less than 10 ppb in industrial wastewater without the addition of nutrients. The effect of wastewater pH on the system performance was also evaluated; and wastewater samples with pH values of 6 or 8 were treated efficiently without pH adjustment. These results suggest that a biotreatment system using NP-degrading bacteria can efficiently remediate industrial wastewater and contribute to the preservation of aquatic environments.

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A Survey of Estrogenic Activity in United Kingdom Inland Waters

Cited by 116 publications

References 0 publications

Determination of Steroid Estrogens in Wastewater Treatment Plant of A Controceptives Producing Factory

Determination of Steroid Estrogens in Wastewater Treatment Plant of A Controceptives Producing Factory

Use of vitellogenin mRNA as a biomarker for endocrine disruption in feral and cultured fish

Potential of a new biotreatment: Sphingomonas cloacae S-3 T degrades nonylphenol in industrial wastewater

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