A survey of EPA/OPP and open literature on selected pesticide chemicals III. Mutagenicity and carcinogenicity of benomyl and carbendazim

McCarroll, Nancy; Protzel, Alberto; Ioannou, Y; Stack, H.Frank; Jackson, Marcus; Waters, Michael D.; Dearfield, Kerry L.

doi:10.1016/s1383-5742(02)00026-1

Cited by 90 publications

(47 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The methyl benzimidazole carbamate (MBC) fungicides are known to impact mitosis and cell division in target fungi [59,60]. Previous research revealed the inhibitory effects of these fungicides on the polymerization of tubulin into microtubules.…”

Section: Effects On Mitosis and Cell Divisionmentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

View full text Add to dashboard Cite

Fungicides have been used widely in order to control fungal diseases and increase crop production. However, the effects of fungicides on microorganisms other than fungi remain unclear. The modes of action of fungicides were never well classified and presented, making difficult to estimate their possible nontarget effects. In this paper, the action modes and effects of fungicides targeting cell membrane components, protein synthesis, signal transduction, respiration, cell mitosis, and nucleic acid synthesis were classified, and their effects on nontarget microorganisms were reviewed. Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.

show abstract

Section: Effects On Mitosis and Cell Divisionmentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Synthetic fungicides, for instance, are generally effective and inexpensive, but it has been suggested that they leave residual toxicity that may have carcinogenic and teratogenic side effects (McCarroll et al, 2002). Moreover, most of the synthetic fungicides have been restricted or banned in several countries since the early 1960s (Glamočlija et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antifungal and antibacterial activities of Petroselinum crispum essential oil

et al. 2016

View full text Add to dashboard Cite

ABSTRACT. Parsley [Petroselinum crispum (Mill.) Fuss] is regarded as an aromatic, culinary, and medicinal plant and is used in the cosmetic, food, and pharmaceutical industries. However, few studies with conflicting results have been conducted on the antimicrobial activity of parsley essential oil. In addition, there have been no reports of essential oil obtained from parsley aerial parts, except seeds, as an alternative natural antimicrobial agent. Also, microorganism resistance is still a challenge for health and food production. Based on the demand for natural products to control microorganisms, and the reevaluation of potential medicinal plants for controlling diseases, the objective of this study was to determine the chemical composition and antibacterial and antifungal activities of parsley essential oil against foodborne diseases and opportunistic pathogens. Seven bacteria and eight fungi were tested. The essential oil major compounds were apiol, myristicin, and b-phellandrene. Parsley essential oil had bacteriostatic activity against all tested bacteria, mainly Staphylococcus aureus, Listeria monocytogenes, and Salmonella enterica, at similar or lower concentrations than at least one of the controls, and bactericidal activity against all tested bacteria, mainly S. aureus, at similar or lower concentrations than at least one of the controls. This essential oil also had fungistatic activity against all tested fungi, mainly, Penicillium ochrochloron and Trichoderma viride, at lower concentrations than the ketoconazole control and fungicidal activity against all tested fungi at higher concentrations than the controls. Parsley is used in cooking and medicine, and its essential oil is an effective antimicrobial agent.

show abstract

“…MBC also is the hydrolytic product and active component of some other widely used systemic fungicides, such as benomyl and thiophenate methyl (9,17). MBC is quite stable in soil and water, which in turn can lead to the contamination of foodstuffs (4,6,7,12,24).…”

mentioning

confidence: 99%

Cloning and Biochemical Characterization of a Novel Carbendazim (Methyl-1 H -Benzimidazol-2-ylcarbamate)-Hydrolyzing Esterase from the Newly Isolated Nocardioides sp. Strain SG-4G and Its Potential for Use in Enzymatic Bioremediation

Pandey

Dorrian

Russell

et al. 2010

Appl Environ Microbiol

View full text Add to dashboard Cite

A highly efficient carbendazim (methyl-1H-benzimidazol-2-ylcarbamate, or MBC)-mineralizing bacterium was isolated from enrichment cultures originating from MBC-contaminated soil samples. This bacterium, Nocardioides sp. strain SG-4G, hydrolyzed MBC to 2-aminobenzimidazole, which in turn was converted to the previously unknown metabolite 2-hydroxybenzimidazole. The initial steps of this novel metabolic pathway were confirmed by growth and enzyme assays and liquid chromatography-mass spectrometry (LC-MS) studies. The enzyme responsible for carrying out the first step was purified and subjected to N-terminal and internal peptide sequencing. The cognate gene, named mheI (for MBC-hydrolyzing enzyme), was cloned using a reverse genetics approach. The MheI enzyme was found to be a serine hydrolase of 242 amino acid residues. Its nearest known relative is an uncharacterized hypothetical protein with only 40% amino acid identity to it. Codon optimized mheI was heterologously expressed in Escherichia coli, and the His-tagged enzyme was purified and biochemically characterized. The enzyme has a K m and k cat of 6.1 M and 170 min ؊1 , respectively, for MBC. Radiation-killed, freeze-dried SG-4G cells showed strong and stable MBC detoxification activity suitable for use in enzymatic bioremediation applications.

show abstract

A survey of EPA/OPP and open literature on selected pesticide chemicals III. Mutagenicity and carcinogenicity of benomyl and carbendazim

Cited by 90 publications

References 105 publications

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Antifungal and antibacterial activities of Petroselinum crispum essential oil

Cloning and Biochemical Characterization of a Novel Carbendazim (Methyl-1 H -Benzimidazol-2-ylcarbamate)-Hydrolyzing Esterase from the Newly Isolated Nocardioides sp. Strain SG-4G and Its Potential for Use in Enzymatic Bioremediation

Contact Info

Product

Resources

About