Liquid rocket engine design, manufacturing, and testing require implementation of a robust systems engineering process to be successful. In addition to propulsion, there are multiple disciplines involved, including thermal, structures, structural dynamics, electrical engineering, and fluid dynamics. There are also significant interface challenges when integrating the engine system with the launch vehicle. The overall process requires a balance of often competing requirements, including cost, schedule, performance, and reliability. Application of the systems engineering process to liquid rocket engine system design and test evaluation is described in this chapter. Considerations for several system design requirements are covered, including human rating and reliability. After an engine is designed and manufactured, extensive testing and evaluation are required to confirm analytical model predictions and assumptions. Engine testing processes are described to provide an overview of test objectives and requirements. Development testing is used to characterize engine operation and to identify failure modes before qualification begins. Qualification test requirements and flight test demonstration goals will also be reviewed. Finally, systems engineering tools, which are available to prevent and resolve failures, are summarized with specific application to liquid rocket propulsion systems described.