A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea

Kim, Eu Suk; Song, Jin Su; Lee, Hye Jin; Choe, Pyoeng Gyun; Park, Kyung Hwa; Cho, Jae Hyun; Park, Wan Beom; Kim, Sung-Han; Bang, Ji Hwan; Kim, Dong-Min; Park, Kyoung Un; Shin, Sue; Lee, Mi Suk; Choi, Hee Jung; Kim, Nam Joong; Kim, Eui Chong; Oh, Myoung Don; Kim, Hong Bin; Choe, Kang Won

doi:10.1093/jac/dkm309

Cited by 131 publications

(69 citation statements)

References 35 publications

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“…There are also growing concerns about increasing methicillin-resistant S. aureus (MRSA) infections in both community and nosocomial settings. Although rates of community-associated (CA) MRSA infection are still low in Korea, MRSA accounts for over 60% of S. aureus nosocomial isolates, and there has also been a shift to increasing rates of CA-MRSA disease [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Characteristics of invasive Staphylococcus aureus infections in three regions of Korea, 2009-2011: a multi-center cohort study

et al. 2013

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BackgroundDespite the importance of invasive Staphylococcus aureus (ISA) infection, its overall burden in non-selected populations has only been defined in a small number of studies in Europe and North America. To define the characteristics of ISA infections in Korea, we conducted a multi-center cohort study to estimate population-based incidence rates.MethodsWe conducted a multicenter prospective cohort study at nine university-affiliated active-surveillance core centers (ASCs) in three regions of Korea. To cover all available clinical microbiologic laboratories, we classified the laboratories in these regions into three groups according to their clinical environment as: 1) Nine ASCs, 2) Five major commercial laboratories and 3) Forty-four acute-care hospital-affiliated microbiology laboratories. We requested all the laboratories to report prospectively their numbers of cases of S. aureus isolated from normally sterile sites. Detailed clinical information was collected about the cases in the nine ASCs.ResultsFrom 1 July 2009 to 30 June 2011, a total of 1,198 cases of ISA infection were identified at the nine ASCs, including 748 (62%) methicillin-resistant S. aureus (MRSA) infections. Most (81%) ISA infections were healthcare-associated (HCA): 653 (55%) hospital-onset and 322 (27%) community-onset. 223 (19%) were community-associated infections. The most common primary diagnosis was catheter-associated infection (225 cases, 19%). Respiratory tract infection (160, 13%), skin & soft tissue (152, 13%) and bone & joint infections (120, 10%) were also common. 30-day and 12-week mortality rates were 25.6% (262/1,024) and 36.5% (314/860), respectively. Complications, including metastatic infection within 12 weeks, occurred in 17.8% of ISA infections. The most common site of metastatic infection was the lung (9.8%, 84/860). Based on the total of 2,806 observed cases of ISA infection, estimated annual rates of ISA and invasive MRSA infections were 43.3 and 27.7 per 100,000 populations, respectively.ConclusionsOur data provide important information about the clinical characteristics of ISA infections. We estimate that over 21,000 ISA infections and 13,000 invasive MRSA infections occurred in Korea in 2010.

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Section: Introductionmentioning

confidence: 99%

Characteristics of invasive Staphylococcus aureus infections in three regions of Korea, 2009-2011: a multi-center cohort study

et al. 2013

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“…Invasive S. aureus (ISA) infections, defined as the isolation of S. aureus from a normally sterile site (e.g., bacteremia), are associated with high morbidity and mortality (1). Methicillin-resistant S. aureus (MRSA) accounts for about 60% of nosocomial S. aureus infections, and community-associated MRSA disease has been increasing in Korea (1,2). Although new antistaphylococcal antibiotics have been developed, vancomycin retains the first-line position as treatment for MRSA infections (3).…”

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confidence: 99%

Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections

Song

Kim

Cho

et al. 2017

Antimicrob Agents Chemother

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There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes in Staphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasive S. aureus (ISA) infections, defined as the isolation of S. aureus from a normally sterile site. Over a 2-year period, 1,027 adult patients with ISA infections were enrolled in 10 hospitals, including 673 (66%) patients with methicillin-resistant S. aureus (MRSA) infections. There were 200 (19.5%) isolates with high VAN-MIC (Ն1.5 mg/liter) by Etest and 87 (8.5%) by broth microdilution (BMD). The all-cause 30-day mortality rate was 27.4%. High VAN-MIC by either method was not associated with all-cause 30-day mortality, and this finding was consistent across MIC methodologies and methicillin susceptibilities. We conclude that high VAN-MIC is not associated with increased risk of all-cause 30-day mortality in ISA infections. Our data support the view that VAN-MIC alone is not sufficient evidence to change current clinical practice.

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“…In addition, the recent emergence and spread of community-associated MRSA (CA-MRSA) in health care settings have increased the importance of this microorganism (4). CA-MRSA has also emerged as an important pathogen in South Korea (5), where its genetic profile differs markedly from that in other countries (6)(7)(8).…”

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agr Dysfunction Affects Staphylococcal Cassette Chromosome mec Type-Dependent Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Bacteremia

Kang

Cho

Choi

et al. 2015

Antimicrob Agents Chemother

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A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea

Abstract: Despite MRSA-endemic hospital settings, CA-MRSA infections are not common in Korea. A new clone of CA-MRSA, ST72-SCCmec type IVa without the PVL gene, is the most common form.

Cited by 131 publications

References 35 publications

Characteristics of invasive Staphylococcus aureus infections in three regions of Korea, 2009-2011: a multi-center cohort study

Characteristics of invasive Staphylococcus aureus infections in three regions of Korea, 2009-2011: a multi-center cohort study

Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections

agr Dysfunction Affects Staphylococcal Cassette Chromosome mec Type-Dependent Clinical Outcomes in Methicillin-Resistant Staphylococcus aureus Bacteremia

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