A surgical polypragmasy: Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. J Ovarian Res. 2013 Dec 11;6(1):90

Mynbaev, Ospan A.; Bíró, Péter; Eliseeva, Marina Yu; Tinelli, Andrea; Malvasi, Antonio; Kosmas, Ioannis; Медведєв, М. В.; Babenko, Tatiana; Mazitova, M. I.; Simakov, Sergey; Stark, Michael

doi:10.1186/1757-2215-7-29

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…There are also concerns that some of these studies include multiple additional factors such as cooling and humidifying the gas as part of their intervention. As mentioned in the results section, there is some discrepancy between full and limited “conditioning” and a letter to Koninckx's (2013) translational study also touched on this [ 34 ]. The letter highlighted that it is challenging to distinguish the weighting and efficacy of each factor involved in adhesion prevention.…”

Section: Discussionmentioning

confidence: 99%

Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions

Chen,

Dasgupta,

Vasdev

2024

J Robotic Surg

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The formation of pneumoperitoneum involves the process of inflating the peritoneal cavity during laparoscopic and typically uses CO2 as the insufflation gas. This review aims to identify ideal gas mixtures for establishing the pneumoperitoneum with animal and human studies undertaken up to the writing of this review. A systematic search of PubMed, OVID, and clinicaltrials.gov was performed to identify studies on the utilisation of mixed gases in laparoscopic surgery, including non-randomised/randomised trials, animal and human studies, and studies with inflating pressures between 12 and 16 mmHg. ROBINS-I and RoB2 tool was used to assess the risk of bias. A narrative synthesis of results was performed due to the heterogeneity of the studies. 5 studies from the database search and 5 studies from citation search comprising 128 animal subjects and 61 human patients were found. These studies collated results based on adhesion formation (6 studies), pain scores (2 studies) and other outcomes, with results favouring the use of carbon dioxide + 10% nitrous oxide + 4% oxygen. This has shown a significant reduction in adhesion formation, pain scores and inflammation. The use of this gas mixture provides promising results for future practice. Several of the studies available require larger sample sizes to develop a more definitive answer on the effects of different gas mixtures. Furthermore, the number of confounding factors in randomised trials should be reduced so that each component of the current suggested gas mixture can be tested for safety and efficacy.

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Section: Discussionmentioning

confidence: 99%

Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions

Chen,

Dasgupta,

Vasdev

2024

J Robotic Surg

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“…CO 2 -pneumoperitoneum is the necessary condition to create a working space to perform manipulations during laparoscopic surgery. High amount of CO 2 in the abdominal cavity unnaturally accelerates a basic chemical reaction of CO 2 and water with carbonic acid formation and its subsequent dissociation into hydrogen and bicarbonate ions, which is associated with CO 2 -pneumoperitoneum side effects [61]. Subsequently literature concerning tissue-blood CO 2 exchange, peritoneal tissue pH changes during CO 2 -pneumoperitoneum as well as CO 2 -insufflation pressure-dependent extra/intra intracellular pH, and cell culture media pH changes CO 2 insufflation pressure-dependent synchronous arterial & venous blood gas changes was comprehensively analyzed and concept of CO 2 homeostasis during laparoscopic surgery was developed.…”

Section: Prof Ospan a Mynbaev And Coll From Moscowmentioning

confidence: 99%

Nesa Days 2015, Conference Report

Tinelli¹

2015

Int. J. Gynecol. Obstet. & Neona. Care

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Belgian consensus on adhesion prevention in hysteroscopy and laparoscopy

Verguts

Bosteels

Roberta³

et al. 2015

Gynecol Surg

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Intrauterine and intraabdominal adhesions are a major cause for infertility. The most recent investigations have demonstrated the potential of intraperitoneal adhesion barriers combined with good surgical technique to reduce adhesion formation. For intrauterine adhesions we suggest to minimize unipolar and bipolar instrumentation whenever possible. We advocate the use of estrogens for 10 days after adhesiolysis: 2dd two tablets of estradiol 2 mg. Instillation of Hyalobarrier Gel Endo actually is not reimbursed but may have a beneficial effect after myomectomy or adhesiolysis. Concerning laparoscopic and laparotomic prevention of adhesion also, meticulous surgical technique is of the utmost importance. Residual blood should be avoided by careful hemostasis and rinsing with Ringer's lactate with heparin. Preferably braided sutures are not to be left in the abdominal cavity. We advise to avoid unipolar and bipolar cauterization when possible and to replace with ultrasonic or laser energy. The use of floatation barriers does not seem to add substantial benefit in the prevention of adhesions. Gel barriers (Hyalobarrier Gel Endo® or Intercoat®) are proven to have a significant effect on adhesion prevention. As for sheets, there is enough evidence that they prevent adhesions. The use of NSAID in the prevention of pain and/or corticosteroids in the prevention of postoperative nausea is already mainstay after surgery and can be further endorsed in the prevention of adhesions.

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A surgical polypragmasy: Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. J Ovarian Res. 2013 Dec 11;6(1):90

Cited by 5 publications

References 18 publications

Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions

Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions

Nesa Days 2015, Conference Report

Belgian consensus on adhesion prevention in hysteroscopy and laparoscopy

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